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PXD036558

PXD036558 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNovel insights into redox-based mechanisms for auranofin- induced rapid cancer cell death
DescriptionOne of the significant features of cancer cells is a persistent pro-oxidative status. Therefore, compared to their normal counterparts, the malignant cells are generally more dependent on antioxidants for cell survival and more vulnerable to further oxidative insults via pharmacolog-ical interventions targeting cellular redox systems. This is the biological basis of oxidative stress- or redox-based anticancer strategies. Auranofin (AUF) is a promising repositioning anti-cancer molecule with a multifaceted mode of action that could be cancer cell type- or dose-dependent. Using triple-negative breast cancer cells, we evidenced that thioredoxin reduc-tase inhibition, the best-studied anticancer activity of AUF, is not sufficient to induce efficient cell death. Cytotoxic doses of AUF trigger rapid and global intracellular oxidative stress. Based on the indications from redox proteome data, we showed experimentally that AUF treatment triggered a dose-dependent S-phase arrest and disintegration of actin cytoskeleton structure. These findings on AUF-induced early effects should provide novel insights into the anticancer mechanisms of this promising molecule
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:25:25.052.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJean-Michel Camadro
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListbiotinylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-08 06:35:49ID requested
12023-03-10 18:22:16announced
22023-11-14 08:25:27announced2023-11-14: Updated project metadata.
Publication List
Hatem E, El Banna N, Heneman-Masurel A, Ba, ï, lle D, Vernis L, Riquier S, Golinelli-Cohen MP, Guittet O, Valli, è, res C, Camadro JM, Qiu X, Hildebrandt N, Lepoivre M, Huang ME, Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death. Cancers (Basel), 14(19):(2022) [pubmed]
Keyword List
ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: auranofin
oxidative stress
redox regulation
redoxome
cancer
Contact List
Huang Meng-Er
contact affiliationInstitut de Chimie des Substances Naturelles, CNRS, France
contact emailmeng-er.huang@cnrs.fr
lab head
Jean-Michel Camadro
contact affiliationInstitut Jacques Monod Université Paris Cité, CNRS
contact emailjean-michel.camadro@ijm.fr
dataset submitter
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Dataset FTP location
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