PXD036544

PXD036544 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of Adnp mutant mice
Description	We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrease in ADNP protein levels to ~10% of newborn levels in juveniles. In addition, Adnp-mutant adults show abnormally enhanced long-term potentiation in adults but not in juveniles. This accompanies CaMKIIa hyperactivity involving increased baseline autophosphorylation, as revealed by unbiased proteomic analyses.
HostingRepository	MassIVE
AnnounceDate	2023-07-11
AnnouncementXML	Submission_2023-07-11_04:52:46.232.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Heeyoun Hwang
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-05 19:09:07	ID requested
⏵ 1	2023-07-11 04:52:46	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: ADNP syndrome, Autism spectrum disorders, LC-MS/MS, Cognitive inflexibility

submitter keyword: ADNP syndrome, Autism spectrum disorders, LC-MS/MS, Cognitive inflexibility

Contact List

Jin Young Kim
contact affiliation	Korea Basic Science Institute
contact email	jinyoung@kbsi.re.kr
lab head
Heeyoun Hwang
contact affiliation	KBSI
contact email	heeyounh@kbsi.re.kr
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000090257/