PXD036542

PXD036542 is an original dataset announced via ProteomeXchange.

Title	Succinate mediates inflammation-induced adrenocortical dysfunction
Description	Inflammation leads the hypothalamus-pituitary-adrenal (HPA) axis activation and increased production of glucocorticoids, which produced by the adrenal cortex, exert potent anti-inflammatory effects. The use of omics, including proteomics revealed metabolic changes in steroidogenic adrenocortical cells, including downregulation of the tricarboxylic acid (TCA) cycle and oxidative phosphorylation, decreased ATP production and induction of oxidative stress after lipopolysaccharide (LPS)-induced inflammation.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:06.085.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Evangelia Thanou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-05 10:41:37	ID requested
1	2023-07-21 06:56:01	announced
⏵ 2	2023-11-14 09:04:11	announced	2023-11-14: Updated project metadata.

Mateska I, Witt A, Hagag E, Sinha A, Yilmaz C, Thanou E, Sun N, Kolliniati O, Patschin M, Abdelmegeed H, Henneicke H, Kanczkowski W, Wielockx B, Tsatsanis C, Dahl A, Walch AK, Li KW, Peitzsch M, Chavakis T, Alexaki VI, Succinate mediates inflammation-induced adrenocortical dysfunction. Elife, 12():(2023) [pubmed]

submitter keyword: succinate,proteomics, TCA cycle, lipopolysaccharide (LPS), adrenal gland, glucocorticoids

Ka Wan Li
contact affiliation	Center of Neurogenomics and Cognitive Research (CNCR), Department of Molecular and Cellular Neurobiology, Vrije Universiteit, Amsterdam, Netherlands
contact email	k.w.li@vu.nl
lab head
Evangelia Thanou
contact affiliation	Center for Neurogenomics and Cognitive Research, Department of Molecular and Cellular Neurobiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
contact email	e.thanou@vu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD036542

PRIDE project URI

• PRIDE
  1. PXD036542
     1. Label: PRIDE project
     2. Name: Succinate mediates inflammation-induced adrenocortical dysfunction