PXD036533

PXD036533 is an original dataset announced via ProteomeXchange.

Title	Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer
Description	Vesicular genes are crucial to the development of colorectal cancer. Understanding the molecular pathways behind colorectal carcinogenesis and identifying possible treatment targets can be accomplished by analyzing alterations in vesicle genes at multi-omics. Studies on the overall alteration of vesicle genes in colorectal cancer are still lacking, nevertheless. In order to identify a potential association between vesicle genetic alterations and CRC progression, we analyzed molecular alterations in CRC vesicle genes at eight levels in this study, including mRNA, protein, and epigenetic levels. We also analyzed CRC overall survival related genes that were obtained from public database. The analysis of the proteins, chromatin structural variants (SVs), DNA methylation, chromatin accessibility, phosphorylation, ubiquitination, and malonylation of our collected CRC tissues in combination with the RNA-seq data from the TCGA database revealed the presence of multiple levels of alterations in CRC vesicle genes. We progressively examined the alterations of vesicle genes in mRNA and protein levels in CRC and discovered the hub genes COL5A1 and HSPA8. Further investigation identified the probable essential transcription factors YY1, CDX2, and CBX3. This study contributes to a thorough knowledge of the connection between vesicle genes alterations in multiple level and the development of CRC and offers a theoretical framework for the identification of novel treatment targets.
HostingRepository	PRIDE
AnnounceDate	2024-05-23
AnnouncementXML	Submission_2024-05-23_00:54:15.402.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xi Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-05 09:50:05	ID requested
⏵ 1	2024-05-23 00:54:16	announced

Wang X, Wu MM, Zhang W, Liu ZQ, Xu MQ, Zhang FM, He ZQ, Tang DE, Tang M, Dai Y, Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer. Am J Cancer Res, 14(3):1402-1418(2024) [pubmed]

10.62347/qfkd1805;

submitter keyword: CRC

Vesicular genes (VGs)

Multi-omics

Xi Wang
contact affiliation	Shenzhen People’s Hospital
contact email	342031447@qq.com
lab head
Xi Wang
contact affiliation	Shenzhen People's Hospital
contact email	342031447@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD036533

PRIDE project URI

• PRIDE
  1. PXD036533
     1. Label: PRIDE project
     2. Name: Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer