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PXD036500

PXD036500 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQilong Quyu formula ameliorates against cerebral ischemia/reperfusion injury in a mouse model through suppressing ferroptosis
DescriptionIschemic stroke (IR), a leading cause of death worldwide, is one of the most common disorders of the central nervous system and has a poor prognosis. Our previous clinical study had found that Qilong Quyu (QLQY) formula, a currently used hospital preparation derived from classical prescription of TCM, could improve the neurological deficits of the patients suffering stroke. However, the neuroprotective mechanism of QLQY formula remains unclear. In this study, firstly we confirmed that QLQY formula treatment could significantly alleviate ischemia reperfusion (IR)-induced infarct volume and neuronal death in a dose-dependent manner in middle cerebral artery occlusion (MCAO) model mice. Then, proteomics analysis was performed between MCAO model mice treated orally with or without QLQY formula. In total, 85 differentially expressed proteins (DEPs) were observed in mice after QLQY formula treatment, of which 24 DEPs were upregulated and 61 DEPs were downregulated. Based on Kyoto Encyclopedia of Genes and Genomes (
HostingRepositoryiProX
AnnounceDate2022-09-05
AnnouncementXMLSubmission_2022-09-05_00:35:12.680.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJie Wang
SpeciesList scientific name: Mus ; NCBI TaxID: 10088;
ModificationListNo PTMs are included in the dataset
InstrumentThermo Fisher Scientific instrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-05 00:21:45ID requested
12022-09-05 00:35:13announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Cerebral ischemia,Qilong Quyu formula,proteomics,ferroptosis
Contact List
Dezhi Liu
contact affiliationDepartment of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
contact emailyzldz@126.com
lab head
Jie Wang
contact affiliationshuguang hospital affiliated to shanghai University Of TCM
contact emailwangjieyct@163.com
dataset submitter
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