PXD036500
PXD036500 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Qilong Quyu formula ameliorates against cerebral ischemia/reperfusion injury in a mouse model through suppressing ferroptosis |
Description | Ischemic stroke (IR), a leading cause of death worldwide, is one of the most common disorders of the central nervous system and has a poor prognosis. Our previous clinical study had found that Qilong Quyu (QLQY) formula, a currently used hospital preparation derived from classical prescription of TCM, could improve the neurological deficits of the patients suffering stroke. However, the neuroprotective mechanism of QLQY formula remains unclear. In this study, firstly we confirmed that QLQY formula treatment could significantly alleviate ischemia reperfusion (IR)-induced infarct volume and neuronal death in a dose-dependent manner in middle cerebral artery occlusion (MCAO) model mice. Then, proteomics analysis was performed between MCAO model mice treated orally with or without QLQY formula. In total, 85 differentially expressed proteins (DEPs) were observed in mice after QLQY formula treatment, of which 24 DEPs were upregulated and 61 DEPs were downregulated. Based on Kyoto Encyclopedia of Genes and Genomes ( |
HostingRepository | iProX |
AnnounceDate | 2022-09-05 |
AnnouncementXML | Submission_2022-09-05_00:35:12.680.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jie Wang |
SpeciesList | scientific name: Mus |
ModificationList | No PTMs are included in the dataset |
Instrument | Thermo Fisher Scientific instrument model |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-09-05 00:21:45 | ID requested | |
⏵ 1 | 2022-09-05 00:35:13 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Cerebral ischemia,Qilong Quyu formula,proteomics,ferroptosis |
Contact List
Dezhi Liu | |
---|---|
contact affiliation | Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine |
contact email | yzldz@126.com |
lab head | |
Jie Wang | |
contact affiliation | shuguang hospital affiliated to shanghai University Of TCM |
contact email | wangjieyct@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |