PXD036478

PXD036478 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Adenosine-rich extract of Ganoderma lucidum: a safe and effective lipid-lowering substance via regulating expression and modulation of PPAR signaling pathway
Description	Ganoderma lucidum is a traditional Chinese medicine with a variety of active compounds and possessing adequate lipid-lowering and anti-atherosclerotic effects. However, its main active components and potential mechanisms still remain unclear. Here, we evaluated the anti-hyperlipidemic effect of the adenosine extract from Ganoderma lucidum (AEGL) in high-fat-diet (HFD)-induced hyperlipidemic ApoE-/- mice and explored the underlying biological mechanism by multi-omics analysis. Treatment with AEGL for 8 weeks significantly decreased the serum levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) by 45.59%, 41.22%, and 39.02%, respectively, as well as reduced liver TC and TG by 44.15% and 76.23%, compared with the HFD-only group. We also observed significant amelioration of hepatic steatosis without liver and kidney damage after AEGL treatment. Regulating the expression and acetylation/crotonylation of proteins involved in the PPAR signaling pathway may be one of the potential mechanisms involved in the observed lipid-lowering effects of AEGL.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:42:09.434.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wu shengxian
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-02 06:35:41	ID requested
1	2023-03-11 03:39:12	announced
⏵ 2	2023-11-14 08:42:11	announced	2023-11-14: Updated project metadata.

Publication List

Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S, Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance. iScience, 25(11):105214(2022) [pubmed]

Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S, Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance. iScience, 25(11):105214(2022) [pubmed]

Keyword List

submitter keyword: Hyperlipidemia
Adenosine extract of Ganoderma lucidum (AEGL)
Protein post-translational modifications
Proteomics
Lipidomics

submitter keyword: Hyperlipidemia

Adenosine extract of Ganoderma lucidum (AEGL)

Protein post-translational modifications

Proteomics

Lipidomics

Contact List

Shengxian Wu
contact affiliation	Dongzhimen Hospital, Beijing University of Chinese Medicine
contact email	wushengxianabcd@163.com
lab head
Wu shengxian
contact affiliation	Corresponding author
contact email	wushengxianabcd@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD036478
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD036478

PRIDE project URI

Repository Record List

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