PXD036393 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Hypothesis-generating Proteome Perturbation to Identify Molecular Modes of Drug Action: NEU-4438 and Acoziborole in the African Trypanosome |
Description | Aim of the project was to investigate drug induced proteomic changes in T. brucei within 6 h of treatment with NEU-4438 or SCYX-7158 |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:43:22.165.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD036393 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Amrita Sharma |
SpeciesList | scientific name: Trypanosoma brucei; NCBI TaxID: 5691; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-30 04:33:02 | ID requested | |
1 | 2023-03-11 08:54:44 | announced | |
2 | 2023-11-14 08:35:24 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2023-11-14 08:43:32 | announced | 2023-11-14: Updated project metadata. |
Publication List
Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes MJ, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, Ferrins L, Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development. J Med Chem, 62(2):665-687(2019) [pubmed] |
10.6019/PXD036393; |
Sharma A, Cipriano M, Ferrins L, Hajduk SL, Mensa-Wilmot K, Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome. iScience, 25(11):105302(2022) [pubmed] |
Keyword List
submitter keyword: Trypanosoma brucei, Human African Trypanosomiasis, drug-perturbome proteomics, SILAC,NEU-4438, Acoziborole, SCYX-7158 |
Contact List
Amrita Sharma |
contact affiliation | Kennesaw State University |
contact email | asharm37@kennesaw.edu |
lab head | |
Amrita Sharma |
contact affiliation | Kennesaw State University |
contact email | asharm37@kennesaw.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD036393 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036393
- Label: PRIDE project
- Name: Hypothesis-generating Proteome Perturbation to Identify Molecular Modes of Drug Action: NEU-4438 and Acoziborole in the African Trypanosome