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PXD036393

PXD036393 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHypothesis-generating Proteome Perturbation to Identify Molecular Modes of Drug Action: NEU-4438 and Acoziborole in the African Trypanosome
DescriptionAim of the project was to investigate drug induced proteomic changes in T. brucei within 6 h of treatment with NEU-4438 or SCYX-7158
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:43:22.165.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD036393
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAmrita Sharma
SpeciesList scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-30 04:33:02ID requested
12023-03-11 08:54:44announced
22023-11-14 08:35:24announced2023-11-14: Updated project metadata.
32023-11-14 08:43:32announced2023-11-14: Updated project metadata.
Publication List
Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes MJ, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, Ferrins L, Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development. J Med Chem, 62(2):665-687(2019) [pubmed]
10.6019/PXD036393;
Sharma A, Cipriano M, Ferrins L, Hajduk SL, Mensa-Wilmot K, Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome. iScience, 25(11):105302(2022) [pubmed]
Keyword List
submitter keyword: Trypanosoma brucei, Human African Trypanosomiasis, drug-perturbome proteomics, SILAC,NEU-4438, Acoziborole, SCYX-7158
Contact List
Amrita Sharma
contact affiliationKennesaw State University
contact emailasharm37@kennesaw.edu
lab head
Amrita Sharma
contact affiliationKennesaw State University
contact emailasharm37@kennesaw.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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