PXD036341

PXD036341 is an original dataset announced via ProteomeXchange.

Title	Trib3 modulates PPAR-mediated growth inhibition by interfering with the MLL complex in breast cancer cells
Description	Dysregulation of pathways due to mutations on oncogenes or tumor suppressors that leads to aberrant expression or activity of proteins is the most well understood mechanism that drives cancer initiation and progression. TRIB3, a member of the Tribbles family of pseudokinases, is often found dysregulated in cancer and has been associated with breast cancer initiation and metastasis formation. However, the underlying mechanisms by which TRIB3 contributes to these events are far from being understood. In contrast PPAR, a well-known transcription factor that belongs to the superfamily of nuclear receptors, has gained attention in recent years as drug target in breast cancer. PPAR possess anti-proliferative abilities and inducing its expression has been shown beneficial in different cancer models. In this study, we demonstrated that TRIB3 regulates PPAR expression in breast cancer cells and that TRIB3 interacts with the WRAD complex in these cells. We showed that TRIB3 expression influence H3K4me3 levels genome wide and specifically at the PPARG locus. All in all, our study situates TRIB3 as a new epigenetic regulator and represents a new line of research for the Tribbles scientific community, opening the door for future targeted therapeutic interventions for breast cancer patients
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:08:34.757.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Harmjan Vos
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-26 08:00:47	ID requested
1	2022-10-13 09:01:16	announced
⏵ 2	2023-11-14 08:08:39	announced	2023-11-14: Updated project metadata.

Hern, á, ndez-Quiles M, Baak R, Orea-Soufi A, Borgman A, den Haan S, Sobrevals Alcaraz P, Jongejan A, van Es R, Velasco G, Vos H, Kalkhoven E, -Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells. Int J Mol Sci, 23(18):(2022) [pubmed]

submitter keyword: MLL complex, breast cancer cells,Trib3, PPAR

Eric Kalkhoven
contact affiliation	Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands.
contact email	E.Kalkhoven@umcutrecht.nl
lab head
Harmjan Vos
contact affiliation	University Medical Center Utrecht Dept. Molecular Cancer Research
contact email	h.r.vos-3@umcutrecht.nl
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD036341
     1. Label: PRIDE project
     2. Name: Trib3 modulates PPAR-mediated growth inhibition by interfering with the MLL complex in breast cancer cells