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PXD036296

PXD036296 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAnalysis of changes in protein expression in inferior colliculus
DescriptionOne of the most robust behavioural phenotypes in the Fmr1-/ymouse is an increased susceptibility to AGS, which models the sensory hypersensitivity and epileptiform activity seen in FX patients (Berry-Kravis, 2002; Musumeci et al., 1991; Yan et al., 2004; Yan et al., 2005). Multiple therapeutic strategies that alleviate AGS have gone on to be tested in clinical studies, suggesting this assay has predictive value (Liu and Smith, 2014; Michalon et al., 2012; Osterweil et al., 2013; Pacey et al., 2009). Recent studies implicate the inferior colliculus (IC) as a central mediator of the AGS phenotype. The IC is a central hub for auditory processing, relaying information from brainstem nuclei to the auditory cortex and other brain regions (Ayala et al., 2016). In the Fmr1-/ymouse, auditory stimulation causes an enhanced activation of IC neurons as assessed by cFos+ staining and in vivosingle-unit recordings (Nguyen et al., 2020). Moreover, studies using conditional expression of Fmr1in specific neuronal populations show that loss of FMRP in glutamatergic VGlut2+ neurons in the IC is both necessary and sufficient for AGS induction (Gonzalez et al., 2019). We aim to test whether changes in proteasome activity is seen in the Fmr1-/y IC, and if so whether modulating UPS activity could resolve pathological changes.
HostingRepositoryPRIDE
AnnounceDate2025-05-02
AnnouncementXMLSubmission_2025-05-02_02:30:18.961.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJimi Wills
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-25 14:54:14ID requested
12025-05-02 02:30:19announced
Publication List
10.1016/j.neuron.2022.11.012;
Louros SR, Seo SS, Maio B, Martinez-Gonzalez C, Gonzalez-Lozano MA, Muscas M, Verity NC, Wills JC, Li KW, Nolan MF, Osterweil EK, Excessive proteostasis contributes to pathology in fragile X syndrome. Neuron, 111(4):508-525.e7(2023) [pubmed]
Keyword List
submitter keyword: AGS,inferior colliculus, proteasome, Fragile X
Contact List
Emily Osterweil
contact affiliationCentre for Discovery Brain Sciences, University of Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, UK
contact emailEmily.Osterweil@ed.ac.uk
lab head
Jimi Wills
contact affiliationFirefinch Software Ltd formerly Univeristy of Edinburgh
contact emailjimi@firefinch.io
dataset submitter
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Dataset FTP location
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