PXD036258 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | mTOR activity paces human blastocyst stage developmental progression (data set 2) |
Description | Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway1. It is unknown whether this ability is conserved in mammals in general and in humans in particular. Here we show that decreasing the activity of the mTOR signaling pathway induces human pluripotent stem cells (hPSCs) and blastoids to enter a dormant state with limited proliferation, developmental progression, and capacity to attach to endometrial cells. These in vitro assays show that, similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage and is reversible at both functional and molecular levels. The pacing of human blastocyst development has potential implications for reproductive therapies. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-26 |
AnnouncementXML | Submission_2024-09-26_04:43:36.866.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | David Meierhofer |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | timsTOF SCP |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-25 13:03:35 | ID requested | |
⏵ 1 | 2024-09-26 04:43:37 | announced | |
Publication List
Keyword List
submitter keyword: pausing embryonic development |
Contact List
Aydan Bulut-Karslioglu |
contact affiliation | Research Group Leader Bulut-Karslioglu lab Dept. of Genome Regulation Max Planck Institute for Molecular Genetics Ihnestrasse 63-73 14195 Berlin GERMANY |
contact email | Aydan.Karslioglu@molgen.mpg.de |
lab head | |
David Meierhofer |
contact affiliation | Mass Spectrometry Facility MPIMG |
contact email | meierhof@molgen.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036258
- Label: PRIDE project
- Name: mTOR activity paces human blastocyst stage developmental progression (data set 2)