PXD036251
PXD036251 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effects of NMDAR on mouse hippocampal neuron (HT22) proteome expression during hypoxia/reoxygenation injury |
| Description | Brain tissue is extremely sensitive to hypoxia/reoxygenation (H/R) injury, which can easily cause irreversible damage to neurons. H/R injury could induce neuronal apoptosis through glutamate-mediated excitotoxicity. N-methyl-d-aspartate receptor (NMDAR) is one of the main receptors of excitatory glutamate, and blocking NMDAR could protect brain tissue from ischemia and hypoxia injury. NMDAR hypofunction can also cause psychotic symptoms or cognitive impairment. However, there is still a lack of systematic research on the changes of the proteome and transcriptome in neuronal cells under the condition of NMDAR hypofunction and H/R injury. In this study, we compared the changes of proteome expression levels in neurons after NMDAR knockdown and H/R stimulation by isobaric tags for relative and absolute quantitation (iTRAQ). |
| HostingRepository | iProX |
| AnnounceDate | 2022-08-24 |
| AnnouncementXML | Submission_2023-01-12_19:42:00.860.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qiwei Yang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-08-23 23:19:31 | ID requested | |
| 1 | 2022-08-23 23:20:06 | announced | |
| ⏵ 2 | 2023-01-12 19:42:01 | announced | 2023-01-13: Update publication information. |
Publication List
| He J, Chen K, Sui Y, Yang Q, Effects of N-methyl-D-aspartate receptor knockdown and hypoxia/reoxygenation injury on the neuronal proteome and transcriptome. Front Mol Neurosci, 15():1004375(2022) [pubmed] |
Keyword List
| submitter keyword: mouse hippocampal neuron, HT22, NMDAR, hypoxia/reoxygenation injury, iTRAQ |
Contact List
| Qiwei Yang | |
|---|---|
| contact affiliation | Jilin University |
| contact email | yangqw@jlu.edu.cn |
| lab head | |
| Qiwei Yang | |
| contact affiliation | Jilin University |
| contact email | yangqw@jlu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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