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PXD036199

PXD036199 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAn integrated metabolomics and lipidomics approach for the study of metabolic network and early diagnosis in cerebral infarction
DescriptionCerebral infarction (CI) remains a major cause of high mortality and long-term disability worldwide. The exploration of biomarkers and pathogenesis is crucial for early diagnosis of CI. Although the understanding of metabolic perturbations underlying CI has increased in recent years, the relationship between altered metabolites and disease pathogenesis has only been partially elucidated and requires further investigation. Here, we performed an integrated metabolomics and lipidomics analysis on 59 healthy subjects and 47 CI patients. Ultimately, 49 metabolites and 68 lipids biomarkers were identified and enriched in 24 disturbed pathways. The metabolic network revealed a significant interaction between altered lipids and other metabolites. Using ROC analysis, a panel of 3 polar metabolites and 7 lipids was optimized in training set, which was taurine, oleoylcarnitine, creatinine, PE(22:6/P-18:0), Cer 34:2, GlcCer(d18:0/18:0), DG 44:0, LysoPC(16:0), 22:6-OH/LysoPC and TAG58:7-FA22:4. Subsequently, a support vector machine (SVM) model was constructed and validated, which showed an excellent predictive ability in validation set. Thereby, the integrated metabolomics and lipidomics approach could contribute to a comprehensive understanding of the metabolic dyshomeostasis associated with the pathogenesis underlying CI. The present research may promote a deeper understanding and early diagnosis of CI in clinic.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:40:12.115.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXX Y
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ TRAP; TripleTOF 5600; Synapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-21 04:38:42ID requested
12023-03-11 01:53:20announced
22023-11-14 08:40:13announced2023-11-14: Updated project metadata.
Publication List
Ye X, Zhu B, Chen Y, Wang Y, Wang D, Zhao Z, Li Z, Integrated Metabolomics and Lipidomics Approach for the Study of Metabolic Network and Early Diagnosis in Cerebral Infarction. J Proteome Res, 21(11):2635-2646(2022) [pubmed]
Keyword List
submitter keyword: Metabolomics,Cerebral Infarction, LC-MS, Lipidomics, Biomarkers
Contact List
Xinxin Ye
contact affiliationCapital Normal University
contact emaily17702513205@163.com
lab head
XX Y
contact affiliationCapital Normal University
contact emaily17702513205@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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