PXD036141

PXD036141 is an original dataset announced via ProteomeXchange.

Title	PLK1 O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma
Description	The O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) mediates intracellular O-GlcNAcylation modification, whose function and substrates have entranced biologists and chemists alike. O-GlcNAcylation occurs on Ser/Thr residues and takes part in a vast array of physiological processes. OGT is essential for dividing mammalian cells, and it underscores many human diseases. Yet many of its fundamental substrates in the cell division process remains to be unveiled. Here we focus on its effect on Polo-like kinase 1 (PLK1), a mitotic master kinase that governs DNA replication, mitotic entry, chromosome segregation and mitotic exit. We found that PLK1 interacts with OGT and is O-GlcNAcylated.
HostingRepository	iProX
AnnounceDate	2022-08-17
AnnouncementXML	Submission_2023-09-11_20:55:57.899.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guangcan Shao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-17 19:04:56	ID requested
⏵ 1	2023-09-11 20:56:01	announced

Yan S, Peng B, Kan S, Shao G, Xiahou Z, Tang X, Chen YX, Dong MQ, Liu X, Xu X, Li J, Polo-like kinase 1 (PLK1) O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma. J Biol Chem, 299(2):102887(2023) [pubmed]

submitter keyword: PLK1, O-GlcNAc, mitosis, uterine carcinoma, ubiquitination

Jing Li
contact affiliation	Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing
contact email	jing_li@mail.cnu.edu.cn
lab head
Guangcan Shao
contact affiliation	National Institute of Biological Sciences, Beijing
contact email	shaoguangcan@nibs.ac.cn
dataset submitter

iProX dataset URI