PXD036110 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Characterization of the redox proteome in Drosophila melanogaster aging eyes. |
Description | During oxidative stress, reactive oxygen species (ROS) can modify and damage cellular proteins. In particular, the thiol groups of cysteine residues can undergo reversible or irreversible oxidative post-translation modifications (PTMs). Identifying the redox-sensitive cysteines on a proteome-wide scale can provide insight into those proteins that act as redox sensors or become irreversibly damaged upon exposure to high levels of ROS. Aging is accompanied by oxidative stress, and oxygen-rich tissues such as the eye are particularly vulnerable because of its high energy demand and generation of ROS byproducts, which increases the risk for ocular disease. In this study, we profiled the redox proteome of the aging Drosophila eye to identify cysteine residues that are modified by age-associated ROS. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:57:51.101.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD036110 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Emma Doud |
SpeciesList | scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-16 13:57:47 | ID requested | |
1 | 2023-04-27 12:47:35 | announced | |
⏵ 2 | 2023-11-14 08:57:51 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Drosophila eye, oxidative post-translation modifications, redox proteome, aging |
Contact List
Amber Mosley |
contact affiliation | IUSM Biochemistry and Molecular Biology, Center for Proteome Analysis, Indianapolis, IN |
contact email | almosley@iu.edu |
lab head | |
Emma Doud |
contact affiliation | Indiana University School of Medicine |
contact email | edoud@iu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD036110 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036110
- Label: PRIDE project
- Name: Characterization of the redox proteome in Drosophila melanogaster aging eyes.