PXD036110

PXD036110 is an original dataset announced via ProteomeXchange.

Title	Characterization of the redox proteome in Drosophila melanogaster aging eyes.
Description	During oxidative stress, reactive oxygen species (ROS) can modify and damage cellular proteins. In particular, the thiol groups of cysteine residues can undergo reversible or irreversible oxidative post-translation modifications (PTMs). Identifying the redox-sensitive cysteines on a proteome-wide scale can provide insight into those proteins that act as redox sensors or become irreversibly damaged upon exposure to high levels of ROS. Aging is accompanied by oxidative stress, and oxygen-rich tissues such as the eye are particularly vulnerable because of its high energy demand and generation of ROS byproducts, which increases the risk for ocular disease. In this study, we profiled the redox proteome of the aging Drosophila eye to identify cysteine residues that are modified by age-associated ROS.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:57:51.101.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD036110
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Emma Doud
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-16 13:57:47	ID requested
1	2023-04-27 12:47:35	announced
⏵ 2	2023-11-14 08:57:51	announced	2023-11-14: Updated project metadata.

10.6019/PXD036110;

submitter keyword: Drosophila eye, oxidative post-translation modifications, redox proteome, aging

Amber Mosley
contact affiliation	IUSM Biochemistry and Molecular Biology, Center for Proteome Analysis, Indianapolis, IN
contact email	almosley@iu.edu
lab head
Emma Doud
contact affiliation	Indiana University School of Medicine
contact email	edoud@iu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD036110

PRIDE project URI

• PRIDE
  1. PXD036110
     1. Label: PRIDE project
     2. Name: Characterization of the redox proteome in Drosophila melanogaster aging eyes.