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PXD036110

PXD036110 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterization of the redox proteome in Drosophila melanogaster aging eyes.
DescriptionDuring oxidative stress, reactive oxygen species (ROS) can modify and damage cellular proteins. In particular, the thiol groups of cysteine residues can undergo reversible or irreversible oxidative post-translation modifications (PTMs). Identifying the redox-sensitive cysteines on a proteome-wide scale can provide insight into those proteins that act as redox sensors or become irreversibly damaged upon exposure to high levels of ROS. Aging is accompanied by oxidative stress, and oxygen-rich tissues such as the eye are particularly vulnerable because of its high energy demand and generation of ROS byproducts, which increases the risk for ocular disease. In this study, we profiled the redox proteome of the aging Drosophila eye to identify cysteine residues that are modified by age-associated ROS.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:57:51.101.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD036110
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterEmma Doud
SpeciesList scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-16 13:57:47ID requested
12023-04-27 12:47:35announced
22023-11-14 08:57:51announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD036110;
Keyword List
submitter keyword: Drosophila eye, oxidative post-translation modifications, redox proteome, aging
Contact List
Amber Mosley
contact affiliationIUSM Biochemistry and Molecular Biology, Center for Proteome Analysis, Indianapolis, IN
contact emailalmosley@iu.edu
lab head
Emma Doud
contact affiliationIndiana University School of Medicine
contact emailedoud@iu.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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