PXD036100

PXD036100 is an original dataset announced via ProteomeXchange.

Title	Wnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes
Description	The liver has a remarkable capacity to regenerate, which is sustained by the ability of hepatocytes to act as facultative stem cells that, while normally quiescent, re-enter the cell cycle upon injury. In rodents, growth factor signaling is indispensable, whereas Wnt/β-catenin is not required for effective tissue repair. However, molecular networks controlling human liver regeneration remain unclear.
HostingRepository	PRIDE
AnnounceDate	2024-05-22
AnnouncementXML	Submission_2024-05-22_02:09:19.731.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Beusch
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-16 13:41:38	ID requested
⏵ 1	2024-05-22 02:09:20	announced

Oliva-Vilarnau N, Beusch CM, Sabatier P, Sakaraki E, Tjaden A, Graetz L, B, ü, ttner FA, Dorotea D, Nguyen M, Bergqvist F, Sundstr, ö, m Y, M, ü, ller S, Zubarev RA, Schulte G, Tredup C, Gramignoli R, Tietge UJF, Lauschke VM, B signaling synergize to trigger growth factor-free regeneration of adult primary human hepatocytes. Hepatology, 79(6):1337-1351(2024) [pubmed]

10.1097/hep.0000000000000648;

submitter keyword: growth factors, 3D culture., Wnt/β-catenin,Liver regeneration, priming

Volker M. Lauschke
contact affiliation	Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden The Structural Genomics Consortium (SGC), Karolinska Institutet, Stockholm, Sweden
contact email	volker.lauschke@ki.se
lab head
Christian Beusch
contact affiliation	Division of Chemistry I Department of Medical Biochemistry & Biophysics Karolinska Institutet
contact email	christian.beusch@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD036100

PRIDE project URI

• PRIDE
  1. PXD036100
     1. Label: PRIDE project
     2. Name: Wnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes