PXD036081

PXD036081 is an original dataset announced via ProteomeXchange.

Title	The ESX-4 type VII secretion system in required for efficient heme utilization by Mycobacterium tuberculosis
Description	In this study our primary objective was to identify unknown components that are required of Mtb Hm acquisition. Herein, we show that the ancestral ESX-4 type VII secretion system (T7SS) which was thought to be inactive in Mtb is required for efficient Hm utilization. We also identified that the culture filtrate proteins Rv0125 and Rv1085c and the alternative sigma factor SigM are necessary of Hm utilization. Finally, we present the first direct evidence that some mycobacterial PPE proteins are pore forming membrane proteins.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:26:14.987.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Steven Hartson
SpeciesList	scientific name: Acyrthosiphon pisum (Pea aphid); NCBI TaxID: 7029;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-16 08:32:42	ID requested
1	2023-01-31 12:38:50	announced
⏵ 2	2023-11-14 08:26:18	announced	2023-11-14: Updated project metadata.

Mitra A, Ko YH, Cingolani G, Niederweis M, Heme and hemoglobin utilization by Mycobacterium tuberculosis. Nat Commun, 10(1):4260(2019) [pubmed]

submitter keyword: type VII secretion, iron acquisition,Mycobacterium tuberculosis, heme, channel protein, PPE, outer membrane, ESX-4

Avishek Mitra
contact affiliation	Department of Microbiology and Molecular Genetics, Oklahoma State University
contact email	avi.mitra@okstate.edu
lab head
Steven Hartson
contact affiliation	Oklahoma State University
contact email	hartson.steve@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD036081

PRIDE project URI

• PRIDE
  1. PXD036081
     1. Label: PRIDE project
     2. Name: The ESX-4 type VII secretion system in required for efficient heme utilization by Mycobacterium tuberculosis