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PXD036074

PXD036074 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe human host response to monkeypox infection: a proteomic case series study
DescriptionThe rapid rise of Monkeypox (MPX) cases outside previously endemic areas prompt for a better understanding of the disease. We studied the plasma proteome of a group of MPX patients with a similar infection history and clinical manifestation typical for the current outbreak. We report that MPX is associated with a strong plasma proteomic response among nutritional and acute phase response proteins. Moreover, we report a correlation between plasma proteins and disease severity. Contrasting the MPX host response with that of COVID-19, we find a range of similarities, but also important differences. For instance, CFHR1 is induced in COVID-19, but suppressed in MPX, reflecting the different role of the complement system in the two infectious diseases. The partial overlap in response proteins, however, allowed us to explore repurposing of a COVID-19 biomarker panel assay, which resulted in successful patient classification. Hence, our results provide a first proteomic characterization of the MPX human host response, and we reveal a thus far untapped potential for accelerating the response to disease outbreaks through the repurposing of biomarker assays.
HostingRepositoryPRIDE
AnnounceDate2022-09-22
AnnouncementXMLSubmission_2022-09-22_03:23:59.510.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Mülleder
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentSCIEX instrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-16 05:32:34ID requested
12022-09-22 03:23:59announced
Publication List
10.15252/EMMM.202216643;
Keyword List
submitter keyword: monkeypox virus, host response, proteomics, viral infection, Zeno SWATH
Contact List
Markus Ralser
contact affiliationDepartment of Biochemistry, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany 
contact emailmarkus.ralser@charite.de
lab head
Michael Mülleder
contact affiliationCore Facility -High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact emailmichael.muelleder@charite.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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