PXD036051
PXD036051 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Sensitive and Reversible Labeling Strategy Enables Global Mapping of the Core-Fucosylated Glycoproteome on Cell Surfaces |
| Description | Core fucosylation, the attachment of α1,6-fucose to the innermost GlcNAc residue of N-glycans, is a unique protein glycosylation in living organisms. It plays significant roles in diverse physiological and pathological processes, and its upregulation has been observed in many cancers. Core fucosylation has a strong relationship with tumor growth, inva-sion, metastasis, prognosis, and immune evasion. Yet, the details are still largely unknown due to the lack of an effec-tive analytical method. Here, a site-specific and reversible labeling strategy for rapid and sensitive probing core fucosyla-tion was developed. Taking the newly developed strategy, core-fucosylated proteins located on the cell-surface were selectively labeled and analyzed. The profile of cell-surface glycoproteins provides an in-depth understanding of the biological functions of core fucosylation. |
| HostingRepository | iProX |
| AnnounceDate | 2022-08-13 |
| AnnouncementXML | Submission_2023-12-25_19:56:41.600.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuqiu Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | fucosylated |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-08-14 19:25:41 | ID requested | |
| 1 | 2022-08-14 19:26:04 | announced | |
| ⏵ 2 | 2023-12-25 19:56:42 | announced | 2023-12-26: Update information. |
Publication List
| Tian Y, Wang Y, Yin H, Luo Y, Wei F, Zhou H, Wen L, A Sensitive and Reversible Labeling Strategy Enables Global Mapping of the Core-Fucosylated Glycoproteome on Cell Surfaces. Angew Chem Int Ed Engl, 61(49):e202206802(2022) [pubmed] |
Keyword List
| submitter keyword: Core Fucosylation, breast cancer |
Contact List
| Hu Zhou | |
|---|---|
| contact affiliation | Shanghai Institute of Materia Medica |
| contact email | zhouhu@simm.ac.cn |
| lab head | |
| Yuqiu Wang | |
| contact affiliation | East China University of Science and Technology |
| contact email | 995752924@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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