PXD035989 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | BioID of CD25 mutants in B-cell malignancies |
| Description | CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing construct was used as negative control. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-23 |
| AnnouncementXML | Submission_2026-02-22_18:58:37.919.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mark Robinson |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | biotinylated residue |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-08-11 03:08:23 | ID requested | |
| ⏵ 1 | 2026-02-22 18:58:38 | announced | |
Publication List
| Lee J, Sun R, Kume K, Robinson ME, Cheng Z, Cosgun KN, Ma N, Hurtz C, Geng H, Luger SM, Litzow MR, Paietta E, Chen J, Vaidehi N, M, ΓΌ, schen M, Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia. Sci Signal, 19(924):eadw5054(2026) [pubmed] |
| 10.1126/scisignal.adw5054; |
Keyword List
| submitter keyword: LC-MSMS, B-ALL,B-cell, CD25, MCL, BioID, Il2ra |
Contact List
| Markus Muschen |
|---|
| contact affiliation | Yale University |
| contact email | markus.muschen@yale.edu |
| lab head | |
| Mark Robinson |
|---|
| contact affiliation | Center of Molecular and Cellular Oncology, Yale University |
| contact email | mark.robinson@yale.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD035989 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035989
- Label: PRIDE project
- Name: BioID of CD25 mutants in B-cell malignancies
