PXD035970

PXD035970 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis of iron oxide nanoparticles toxicity in rats
Description	Iron oxide nanoparticles (IONPs) are the first generation of nanomaterials approved by the Food and Drug Administration for use as imaging agents and for the treatment of iron deficiency in chronic kidney disease. However, several IONPs-based imaging agents have been withdrawn because of toxic effects and the poor understanding of the underlying mechanisms. This study aimed to evaluate IONPs toxicity via proteomics and to elucidate the underlying mechanism after intravenous administration in rats.
HostingRepository	iProX
AnnounceDate	2022-08-11
AnnouncementXML	Submission_2022-12-13_01:44:28.928.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junyuan Han
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-11 01:37:43	ID requested
1	2022-08-11 01:37:57	announced
⏵ 2	2022-12-13 01:44:30	announced	2022-12-13: Update publication information.

Han J, Tian Y, Wang M, Li Y, Yin J, Qu W, Yan C, Ding R, Guan Y, Wang Q, Proteomics unite traditional toxicological assessment methods to evaluate the toxicity of iron oxide nanoparticles. Front Pharmacol, 13():1011065(2022) [pubmed]

submitter keyword: iron oxide nanoparticles, proteomic, rat

Quanjun Wang
contact affiliation	State Key Laboratory of Toxicology and Medical Countermeasures
contact email	wangquanjunbeijing@163.com
lab head
Junyuan Han
contact affiliation	State Key Laboratory of Toxicology and Medical Countermeasures
contact email	hanjunyuanbeijing@163.com
dataset submitter

iProX dataset URI