Co-immunoprecipitation assays coupled with mass spectrometry identified a series of host factors that could interactwith the OuMV MP and link the MP with various pathways including membrane trafficking, lipid binding, protein phosphorylation and dephosphorylation, RNA binding, cell wall biosynthesis, blue light response, calcium signaling, transport across the plasma membrane, protein folding and homeostasis, proteolysis, and metabolism.