PXD035953

PXD035953 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Arylamine N-Acetyltransferase 1 Knockout Breast Cancer Cells
Description	Description A phase II metabolic enzyme, NAT1 is frequently upregulated in breast cancers. Previous studies have shown that inhibition or depletion of NAT1 in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1 contributes to rapid growth of breast cancer cells. This project evaluated the effects of NAT1 knockdown on the proteome of a breast cancer cell line.hese groups include a parental MDA-MB-231 breast cancer cells and two separate NAT1 knockout (KO) cell lines differing by proliferation rates.
HostingRepository	PRIDE
AnnounceDate	2023-03-11
AnnouncementXML	Submission_2023-03-11_02:17:59.374.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD035953
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	MichaelMerchant
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-10 09:31:02	ID requested
⏵ 1	2023-03-11 02:18:00	announced

Hong KU, Gardner JQ, Doll MA, Stepp MW, Wilkey DW, Benz FW, Cai J, Merchant ML, Hein DW, -acetyltransferase 1 knockout MDA-MB-231 breast cancer cells. Data Brief, 45():108634(2022) [pubmed]

10.6019/PXD035953;

submitter keyword: breast cancer,NAT1, MDA, TMT10plex

David W. Hein,PhD
contact affiliation	David W. Hein, Peter K. Knoefel Endowed Chair of Pharmacology Professor and Chairman Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 505 S. Hancock Street, CTR Rm 303, Louisville, Kentucky 40202. U.S.A. Phone: 502-852-6252. Email: david.hein@louisville.edu
contact email	david.hein@louisville.edu
lab head
MichaelMerchant
contact affiliation	University of Louisville School of Medicine
contact email	michael.merchant@louisville.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD035953

PRIDE project URI

• PRIDE
  1. PXD035953
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Arylamine N-Acetyltransferase 1 Knockout Breast Cancer Cells