PXD035890 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | iTRAQ-Based Quantitative Proteomics Analysis of the Effect of ACT001 on Non-alcoholic Steatohepatitis in Mice |
| Description | Non-alcoholic steatohepatitis (NASH) is considered a progressive stage of non-alcoholic fatty liver disease (NAFLD) that can progress to cirrhosis and hepatocellular carcinoma. ACT001 is a novel sesquiterpene lactone derivative that has been shown to have significant antitumor and anti-inflammatory effects. However, the effect of ACT001 on NASH is unclear.Methionine- and choline-deficient (MCD) diet was fed to C57BL/6J mice for 6 weeks to induce the NASH model.iTRAQ quantitative proteomic analysis was performed to clarify the expression of differential proteins (DEPs) after ACT001 action.381 DEPs, including 162 up-regulated and 219 down-regulated proteins, were identified between the model and ACT001 high-dose groups.the function of DEPs in the proteome and the signaling pathways involved will provide new ideas for the research of new drugs for NASH treatment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-17 |
| AnnouncementXML | Submission_2026-08-16_16:12:47.192.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hui Zhou |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | iTRAQ8plex-116 reporter+balance reagent acylated residue |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-08-08 10:16:56 | ID requested | |
| ⏵ 1 | 2026-08-16 16:12:48 | announced | |
Publication List
| 10.1038/s41598-023-38448-4; |
| Zhou H, Niu B, Wu X, Chu W, Zhou Y, Chen Z, Mi Y, Liu Y, Li P, iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice. Sci Rep, 13(1):11336(2023) [pubmed] |
Keyword List
| submitter keyword: Non-alcoholic steatohepatitis, Inflammation, Proteomics,ACT001, iTRAQ |
Contact List
| Ping Li |
|---|
| contact affiliation | Department of Hepatology, Tianjin Second People’s Hospital, Tianjin, China. Tianjin Research Institute of Liver Diseases, Tianjin, China. |
| contact email | tjlplxg@163.com |
| lab head | |
| Hui Zhou |
|---|
| contact affiliation | Tianjin Medical University |
| contact email | zh93002929@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD035890 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035890
- Label: PRIDE project
- Name: iTRAQ-Based Quantitative Proteomics Analysis of the Effect of ACT001 on Non-alcoholic Steatohepatitis in Mice
