PXD035851

PXD035851 is an original dataset announced via ProteomeXchange.

Title	Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter
Description	We present the 3.3 Å cryo-EM structure of an AA amyloid extracted post-mortem from the diseased kidney of a DSH cat with renal failure. The structure reveals a cross-beta architecture assembled from two 76-residue long proto-filaments. Despite >70% sequence homology to mouse and human SAA, the cat SAA variant adopts a unique amyloid fold exhibiting type-2 polymorphism. Based on shared disease profiles and almost identical sequences, we propose a similar amyloid fold of deposits identified previously in captive cheetah.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:57:50.493.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giulia Mazzini
SpeciesList	scientific name: Felis catus (Cat) (Felis silvestris catus); NCBI TaxID: 9685;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-07 03:41:31	ID requested
1	2022-11-18 06:15:00	announced
⏵ 2	2023-11-14 08:57:50	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: cat, amyloidosis, serum amyloid A

Giovanni Palladini
contact affiliation	Department of Molecular Medicine, University of Pavia, Pavia, Italy Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
contact email	g.palladini@smatteo.pv.it
lab head
Giulia Mazzini
contact affiliation	Fondazione IRCCS Policlinico San Matteo
contact email	g.mazzini@smatteo.pv.it
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD035851
     1. Label: PRIDE project
     2. Name: Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter