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PXD035833

PXD035833 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStructural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland – lessons from a translational pig model
DescriptionGrowth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 but high, non-functional GH levels. This study investigates the histomorphological and molecular alterations associated with GHRD. Pituitary glands from 6 months old GHR-KO pigs and control animals were compared using a quantitative stereological approach and label-free proteomics.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:48:07.243.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBachuki Shashikadze
SpeciesList scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-07 02:55:27ID requested
12023-05-12 04:07:16announced
22023-11-14 08:48:15announced2023-11-14: Updated project metadata.
Publication List
Shashikadze B, Franzmeier S, Hofmann I, Kraetzl M, Flenkenthaler F, Blutke A, Fr, ö, hlich T, Wolf E, Hinrichs A, Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model. J Neuroendocrinol, 36(7):e13277(2024) [pubmed]
Keyword List
submitter keyword: proteomics, Brain,Growth hormone receptor deficiency, pig, animal model
Contact List
Bachuki Shashikadze
contact affiliationLaboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact emailshashikadze@genzentrum.lmu.de
lab head
Bachuki Shashikadze
contact affiliationLaboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact emailshashikadze@genzentrum.lmu.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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