PXD035812

PXD035812 is an original dataset announced via ProteomeXchange.

Title	Detection of Early Prognostic Biomarkers for Metastasis of Ewing’s Sarcoma in Pediatric Patients
Description	Ewing’s sarcoma (ES) is a highly aggressive bone tumor, and the second most prevalent pediatric bone malignancy. The presence of metastasis at diagnosis decreases the three-year survival rate to 20% and contributes to diminished prognosis. Researches are indispensable for the early characterization of the disease and prediction of metastatic-prone patients, through biomarkers identification. Moreover, there is currently no available data on ES utilizing non-biopsy samples, such as plasma. This study utilizes a proteomic analysis of Ewing's sarcoma patient’s plasma samples and biopsies. Initially, the ES group was compared with the control counterpart. In a next step, the ES arm was further stratified into either initially metastatic and non-metastatic, or poor and good chemotherapy responder groups to identify protein expression profiles that can predict metastatic proneness and chemotherapy response, respectively.
HostingRepository	PRIDE
AnnounceDate	2023-12-19
AnnouncementXML	Submission_2023-12-19_04:54:05.063.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sameh Magdeldin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-04 08:00:49	ID requested
⏵ 1	2023-12-19 04:54:05	announced

10.1016/J.LFS.2023.122237;

submitter keyword: Ewing's Sarcoma, mass spectrometry,Proteomics, pediatric cancer, Biomarkers

Sameh Magdeldin
contact affiliation	Head of Proteomics and Metabolomics Research Program, Basic Research department, Children's Cancer Hospital 57357, Ciro, Egypt.
contact email	sameh.magdeldin@57357.org
lab head
Sameh Magdeldin
contact affiliation	Proteomics and Metabolomics Research Program, Basic Research Department, Children’s Cancer Hospital, (CCHE-57357), Cairo 57357, Egypt
contact email	proteomicslab2017@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD035812

PRIDE project URI

• PRIDE
  1. PXD035812
     1. Label: PRIDE project
     2. Name: Detection of Early Prognostic Biomarkers for Metastasis of Ewing’s Sarcoma in Pediatric Patients