PXD035810

PXD035810 is an original dataset announced via ProteomeXchange.

Title	Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes
Description	Opioid use disorder (OUD) is a public health crisis currently being exacerbated by increases in use of fentanyl; therefore, the identification of novel biomarkers and treatment strategies is critical. Here, we define how manipulations of the gut microbiome drive fentanyl intake, fentanyl seeking, and alter proteomic plasticity in the nucleus accumbens. These findings establish clear relevance for gut-brain signaling in OUD, and lay foundations for further translational work in this space.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:41:14.835.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TuKiet Lam
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-04 07:59:41	ID requested
1	2024-05-22 03:23:45	announced
⏵ 2	2024-10-22 06:41:15	announced	2024-10-22: Updated project metadata.

Hofford RS, Meckel KR, Wiser EJ, Wang W, Sens JP, Kim M, Godino A, Lam TT, Kiraly DD, Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids. eNeuro, 11(2):(2024) [pubmed]

10.1523/eneuro.0388-23.2023;

submitter keyword: Nucleus accumbens, quantitative mass spectrometry,Opioid use disorder

Data Independent Acquisition

Gut Microbiome

TuKiet Lam
contact affiliation	Keck MS & Proteomics Resource Yale School of Medicine Department of Molecular Biophysics and Biochemistry Yale University
contact email	tukiet.lam@yale.edu
lab head
TuKiet Lam
contact affiliation	Yale University
contact email	tukiet.lam@yale.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD035810

PRIDE project URI

• PRIDE
  1. PXD035810
     1. Label: PRIDE project
     2. Name: Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes