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PXD035810

PXD035810 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChanges in gut microbiome composition drive fentanyl intake and striatal proteomic changes
DescriptionOpioid use disorder (OUD) is a public health crisis currently being exacerbated by increases in use of fentanyl; therefore, the identification of novel biomarkers and treatment strategies is critical. Here, we define how manipulations of the gut microbiome drive fentanyl intake, fentanyl seeking, and alter proteomic plasticity in the nucleus accumbens. These findings establish clear relevance for gut-brain signaling in OUD, and lay foundations for further translational work in this space.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:41:14.835.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTuKiet Lam
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-04 07:59:41ID requested
12024-05-22 03:23:45announced
22024-10-22 06:41:15announced2024-10-22: Updated project metadata.
Publication List
Hofford RS, Meckel KR, Wiser EJ, Wang W, Sens JP, Kim M, Godino A, Lam TT, Kiraly DD, Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids. eNeuro, 11(2):(2024) [pubmed]
10.1523/eneuro.0388-23.2023;
Keyword List
submitter keyword: Nucleus accumbens, quantitative mass spectrometry,Opioid use disorder
Data Independent Acquisition
Gut Microbiome
Contact List
TuKiet Lam
contact affiliationKeck MS & Proteomics Resource Yale School of Medicine Department of Molecular Biophysics and Biochemistry Yale University
contact emailtukiet.lam@yale.edu
lab head
TuKiet Lam
contact affiliationYale University
contact emailtukiet.lam@yale.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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