PXD035810 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes |
Description | Opioid use disorder (OUD) is a public health crisis currently being exacerbated by increases in use of fentanyl; therefore, the identification of novel biomarkers and treatment strategies is critical. Here, we define how manipulations of the gut microbiome drive fentanyl intake, fentanyl seeking, and alter proteomic plasticity in the nucleus accumbens. These findings establish clear relevance for gut-brain signaling in OUD, and lay foundations for further translational work in this space. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:41:14.835.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | TuKiet Lam |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-04 07:59:41 | ID requested | |
1 | 2024-05-22 03:23:45 | announced | |
⏵ 2 | 2024-10-22 06:41:15 | announced | 2024-10-22: Updated project metadata. |
Publication List
Hofford RS, Meckel KR, Wiser EJ, Wang W, Sens JP, Kim M, Godino A, Lam TT, Kiraly DD, Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids. eNeuro, 11(2):(2024) [pubmed] |
10.1523/eneuro.0388-23.2023; |
Keyword List
submitter keyword: Nucleus accumbens, quantitative mass spectrometry,Opioid use disorder |
Data Independent Acquisition |
Gut Microbiome |
Contact List
TuKiet Lam |
contact affiliation | Keck MS & Proteomics Resource Yale School of Medicine Department of Molecular Biophysics and Biochemistry Yale University |
contact email | tukiet.lam@yale.edu |
lab head | |
TuKiet Lam |
contact affiliation | Yale University |
contact email | tukiet.lam@yale.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD035810 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035810
- Label: PRIDE project
- Name: Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes