PXD035806
PXD035806 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive Proteogenomic Analysis of the Anti-tumor Immunoactivity of a Novel Oncolytic Vesiculovirus in Hepatocellular Carcinoma |
| Description | Oncolytic viruses can effectively unwrap a multimodal anti-tumor activity, encompassing a selective tumor cell killing and promoting a systemic anti-tumor immunity, making them a formidable foe against cancer. Among these, several members of the Rhabdoviridae family are particularly attractive as oncolytic agents due to their natural tumor selectivity and non-pathogenicity in humans. In this study, we demonstrated that intratumorally (IT) administration of Jurona virus (JURV), a novel oncolytic Rhabdovirus, induces dynamic tumor regression in human HCC xenograft and syngeneic models. Our data shows that IT injections of JURV trigger the recruitment and activation of cytotoxic T (CTLs) and decrease the tumor-associated macrophages (TAM) infiltration leading to tumor growth delay in both local and distant murine HCC tumors in a syngeneic model. Moreover, when administered concomitantly, JURV and anti-PD-1 therapy profoundly modulate the tumor microenvironment (TME) via enhanced infiltration of CTLs, suggesting that immune checkpoint blockade therapy could potentiate the immunomodulatory effect of JURV and potentially provide durable anti-tumor immunity. Our analysis of the molecular and cellular mechanism of JURV-medicated anti-cancer activity unveiled that JURV and anti-PD-1 antibodies activate different effectors of the immune system but have complementary anti-tumor activities. Furthermore, our results indicate that the abscopal effect induced by JURV is likely mediated by the mechanism regulating the T helper cell responses. Our work supports the further development of JURV as a novel immunovirotherapy platform for hepatocellular carcinoma. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-05-06 |
| AnnouncementXML | Submission_2025-05-06_09:09:26.659.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD035806 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Stephanie Byrum |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-08-04 07:57:38 | ID requested | |
| ⏵ 1 | 2025-05-06 09:09:27 | announced |
Publication List
| 10.6019/PXD035806; |
| Tesfay MZ, Zhang Y, Ferdous KU, Taylor MA, Cios A, Shelton RS, Simoes CC, Watters CR, Barro O, Elliott NM, Mustafa B, Chamcheu JC, Graham AL, Washam CL, Alkam D, Gies A, Byrum SD, Giorgakis E, Post SR, Kelly T, Ying J, Moaven O, Chabu CY, Fernandez-Zapico ME, Duda DG, Roberts LR, Govindarajan R, Borad MJ, Cannon MJ, Basnakian AG, Nagalo BM, Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade. Mol Ther Oncol, 32(4):200913(2024) [pubmed] |
| 10.1016/j.omton.2024.200913; |
Keyword List
| submitter keyword: Rhabdoviruses |
| hepatocellular carcinoma |
| Jurona virus |
| oncolytic virotherapy |
Contact List
| Bolni M. Nagalo | |
|---|---|
| contact affiliation | Department of Pathology, UAMS, Little Rock, AR, USA 2 The Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA |
| contact email | BMNagalo@uams.edu |
| lab head | |
| Stephanie Byrum | |
| contact affiliation | UAMS |
| contact email | sbyrum@uams.edu |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD035806 |
| PRIDE project URI |
Repository Record List
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