PXD035803 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans |
Description | Circulating osteoprogenitor (COP) are a population of cell in the peripheral circulation that possess functional and phenotypical characteristics of multipotent stromal cells (MSCs). While there is functional overlap, it is not known how COP cells are related to bone marrow (BM)-derived MSCs (BM-MSCs) and other better characterized stromal progenitor populations such as adipose-derived stromal cells (ASCs). This study compares COP cells to BM-MSCs and ASCs through detailed transcriptomic and proteomic analyses. COP cells have a distinct gene and protein expression pattern to BM-MSCs and ASCs, with a significantly stronger immune footprint, likely owing to their hematopoietic lineage. However, they also have a similar pattern of expression BM-MSCs and ASCs, in genes and proteins in progenitor cell differentiation and proliferation pathways. This study shows COP cells to be a unique but functionally similar population to BM-MSCs and ASCs, sharing their proliferation and differentiation capacity, but with a strong immune phenotype, with potential for translational regenerative medicine strategies. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_03:19:24.931.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jennifer Bethard |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-04 07:56:04 | ID requested | |
⏵ 1 | 2024-10-17 03:19:25 | announced | |
Publication List
10.1093/gerona/glae147; |
Feehan J, Tripodi N, Kondrikov D, Wijeratne T, Gimble J, Hill W, Apostolopoulos V, Duque G, Differential Responses to Aging Among the Transcriptome and Proteome of Mesenchymal Progenitor Populations. J Gerontol A Biol Sci Med Sci, 79(9):(2024) [pubmed] |
Keyword List
submitter keyword: Circulating Osteoprogenitor cell |
Circulating osteogenic precursor |
Multilineage Stromal cells |
Adipose-derived stromal cells. |
Contact List
Jack Feehan |
contact affiliation | 1 Department of Medicine - Western Health, The University of Melbourne, Melbourne, Australia The Australian Institute for Musculoskeletal Science (AIMSS), Western Health, Victoria University and The University of Melbourne, Melbourne, Australia 3 Institute for Health and Sport, Victoria University, Melbourne, Australia |
contact email | jfeehan@student.unimelb.edu.au |
lab head | |
Jennifer Bethard |
contact affiliation | Medical University of SC |
contact email | bethard@musc.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD035803 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035803
- Label: PRIDE project
- Name: Integrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans