PXD035773

PXD035773 is an original dataset announced via ProteomeXchange.

Title	Proteogenomics reveals two distinct biological pilocytic astrocytoma subgroups
Description	Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and driven by aberrant MAPK signaling, typically mediated by BRAF alterations. While five-year overall survival rates exceed 95%, tumor recurrence constitutes a major clinical challenge in incompletely resected tumors despite chemotherapeutic or radiation based therapies. Therefore, we used proteogenomics to discern the biological heterogeneity of PA to improve classification of this tumor entity and identify novel therapeutic targets. Our proteogenomics approach integrates RNA sequencing and LC/MS-based proteomic profiling data from a cohort of 58 confirmed, primary PA samples. An integrative genomics approach was conducted to discern the biological heterogeneity of PA and to identify aberrant pathway activation in these biological subgroups. In summary, Pilocytic astrocytomas segregate into two groups where younger patients are significantly associated with Group 1. Importantly, we validate the two distinct biological subgroups in two non-overlapping cohorts. The biological heterogeneity seen here may improve biological classification and reveal novel therapeutic targets specifically useful for non-resectable tumors with high risk of recurrent or progressive disease.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:08:35.100.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD035773
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Maike Langini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-02 10:51:29	ID requested
1	2023-10-24 12:09:31	announced
⏵ 2	2023-11-14 09:08:36	announced	2023-11-14: Updated project metadata.

Picard D, Felsberg J, Langini M, Stachura P, Qin N, Macas J, Reiss Y, Bartl J, Selt F, Sigaud R, Meyer FD, Stefanski A, St, ü, hler K, Roque L, Roque R, Pandyra AA, Brozou T, Knobbe-Thomsen C, Plate KH, Roesch A, Milde T, Reifenberger G, Leprivier G, Faria CC, Remke M, Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma. Acta Neuropathol, 146(4):551-564(2023) [pubmed]

10.6019/PXD035773;

submitter keyword: LC-MSMS,Pilocytic Astrocytoma, brain tumour

Marc Remke
contact affiliation	Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany
contact email	marc.remke@med.uni-duesseldorf.de
lab head
Maike Langini
contact affiliation	Medicines Discovery Catapult
contact email	maike.langini@md.catapult.org.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD035773
     1. Label: PRIDE project
     2. Name: Proteogenomics reveals two distinct biological pilocytic astrocytoma subgroups