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PXD035747

PXD035747 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules Implicated in ALS/FTD
DescriptionEnergy metabolism and membraneless organelles have been implicated in human diseases including neurodegeneration. How energy deficiency regulates ribonucleoprotein particles such as stress granules (SGs) is still unclear. Here we identified a unique type of granules formed under energy deficiency and uncovered the mechanisms by which the dynamics of diverse stressinduced granules are regulated. Severe energy deficiency induced the rapid formation of energy deficiency-induced stress granule (eSGs), whereas moderate energy deficiency delayed the clearance of conventional SGs. The formation of eSGs or the clearance of SGs was regulated by the mTOR-4EBP1-eIF4E pathway or eIF4A1, involving eIF4F complex assembly or RNA condensation, respectively. In ALS patients’ neurons or cortical organoids, the eSG formation was enhanced, and conventional SG clearance was impaired. These results reveal a critical role for intracellular energy in the regulation of diverse granules and suggest that disruptions in energycontrolled granule dynamics may contribute to the pathogenesis of relevant diseases.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:31:43.487.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterchanhyun na
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-02 10:31:04ID requested
12022-10-14 20:49:37announced
22023-11-14 08:31:44announced2023-11-14: Updated project metadata.
Publication List
Wang T, Tian X, Kim HB, Jang Y, Huang Z, Na CH, Wang J, Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules. Nat Commun, 13(1):5584(2022) [pubmed]
Keyword List
submitter keyword: Stress granule
Energy metabolism
ALS/FTD
Protein homeostasis
Contact List
Chan Hyun Na
contact affiliationNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine
contact emailchanhyun@jhmi.edu
lab head
chanhyun na
contact affiliationJohns Hopkins University
contact emailchanhyun.na@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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