PXD035692

PXD035692 is an original dataset announced via ProteomeXchange.

Title	Coronary alarmins as residual risk markers of atherosclerosis under hypolipidemic therapy
Description	Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. A more recent therapy, with encouraging results, to regulate the low-density lipoproteins levels, has been represented by the proprotein convertase subtilisin/kexin type 9 inhibition, a protein with critical role in lipid metabolism.Alarmins are endogenous danger signals that are released or secreted from damaged or dead/dying cells as a result of various insults. These stress-sensing molecules have been correlated with various inflammatory states or diseases. We hypothesize that a specific panel of alarmins could indicate the persistence of silent atherosclerosis residual risk.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:57:51.228.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Felicia Antohe
SpeciesList	scientific name: Oryctolagus cuniculus (Rabbit); NCBI TaxID: 9986;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-01 09:30:22	ID requested
1	2022-10-03 05:15:40	announced
⏵ 2	2023-11-14 08:57:51	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: atherosclerosis, proteomics, residual risk, mass spectrometry, alarmins

Felicia Antohe
contact affiliation	Institute of Cellular Biology and Pathology
contact email	felicia.antohe@icbp.ro
lab head
Felicia Antohe
contact affiliation	Institute of Cellular Biology and Pathology "N. Simionescu"
contact email	felicia.antohe@icbp.ro
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD035692

PRIDE project URI

• PRIDE
  1. PXD035692
     1. Label: PRIDE project
     2. Name: Coronary alarmins as residual risk markers of atherosclerosis under hypolipidemic therapy