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PXD035583

PXD035583 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMultiomic approaches for thyroid cancer diagnosis
DescriptionThyroid cancer is a common endocrine malignancy; however, its diagnosis is not straightforward. The current gold standard for diagnosing thyroid cancer is fine needle aspiration biopsy (FNAB), but when cytological analysis does not provide viable results or samples belong to less defined categories of diagnosis, patients are often referred to diagnostic surgery. Given that not all these nodules require removal, nor all of them are malignant, patients would not necessarily require surgery had the initial FNAB diagnosis been more conclusive. There is therefore a lack of reliable and specific biomarkers for thyroid cancer malignancy, that can complement and improve the current diagnosing methods. “Omics” approaches have gained much attention in the last decade in the field of biomarker discovery for diagnostic and prognostic characterization of various pathophysiological conditions. In this project, proteomics and metabolomics approaches were applied to the same thyroid nodules from patients with benign and malignant lesions. Tissue analysis provided several interesting biomarkers by both proteomics and metabolomics. The combination of these results demonstrated the high energetic and biomass demand of cancer cells, as well as a biomarker panel including 2 free peptides and 2 proteins with high sensitivity and specificity. Together, these results have contributed to increasing the knowledge of thyroid cancer phenotype and corresponding biochemical profiles, as well as providing potential biomarkers for malignancy, and improving diagnostic methodologies.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_09:11:50.479.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSandra Anjo
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListPropionamide
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-25 11:16:18ID requested
12023-10-24 13:31:45announced
22023-11-14 09:11:53announced2023-11-14: Updated project metadata.
Publication List
Coelho M, Capela J, Anjo SI, Pacheco J, Fernandes MS, Amendoeira I, Jones JG, Raposo L, Manadas B, Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer. Int J Mol Sci, 24(19):(2023) [pubmed]
Keyword List
submitter keyword: Mixomics, Tissue, SWATH-MS, Proteomics, Thyroid cancer, Biomarkers
Contact List
Bruno Manadas
contact affiliationCenter for Neuroscience and Cell Biology – University of Coimbra
contact emailbmanadas@gmail.com
lab head
Sandra Anjo
contact affiliation​Center for Neuroscience and Cell Biology – University of Coimbra
contact emailsandra.isabel.anjo@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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