PXD035571

PXD035571 is an original dataset announced via ProteomeXchange.

Title	Proteomic study on the lymphocytes from pregnant Wistar rats females treated with immunosuppressive regimen
Description	Kidney transplantation remains the optimal therapeutical option for end stage kidney disease. Current immunosuppressive regimens are efficient in combating acute kidney rejection. However, the insight in chronic kidney allograft injury remains limited. Simultaneously, pregnancy in kidney recipients appears more prevalent than during dialysis treatment. Due to ethical issues comprehensive studies on the impact of current immunosuppressive regimens on pregnancy are challenging. Omics- technology enables the systemic insight into biology both of immunity and pregnancy beyond up-to-date collected knowledge. The aim of the study was to investigate the proteomic status of lymphocytes obtained from pregnant female rats under immunosuppressive treatment. The group of 10 pregnant Wistar rat females, 5 of which treated with tacrolimus, mofetil mycophenolate and glicocorticosteroids, 5 used as control. The lymphocytes were obtained and analyzed with mass-spectrometry. The outcomes were verified statistically in terms of proteins up- and down regulation.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:41:29.859.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aleksandra Bogucka
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600+

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-25 02:14:37	ID requested
1	2023-03-11 03:09:19	announced
⏵ 2	2023-11-14 08:41:31	announced	2023-11-14: Updated project metadata.

Wojciuk B, Bogucka A, Czaplewska P, Okulewicz P, Wojciechowska-Koszko I, Ciechanowski K, Kabat-Koperska J, Proteomic study on the lymphocytes from pregnant Wistar rat females treated with immunosuppressive regimen. Clin Transl Sci, 16(1):118-127(2023) [pubmed]

submitter keyword: Rat, Lymphocyte, SWATH-MS

Paulina Czaplewska
contact affiliation	Laboratory of Mass Spectrometry, Core Facility Laboratories, Intercollegiate Faculty of Biotechnology UG&MUG, University of Gdansk, Gdansk, Poland
contact email	paulina.czaplewska@ug.edu.pl
lab head
Aleksandra Bogucka
contact affiliation	Justus Liebig University Giessen
contact email	aleksandra.lewandowska@biotech.ug.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD035571

PRIDE project URI

• PRIDE
  1. PXD035571
     1. Label: PRIDE project
     2. Name: Proteomic study on the lymphocytes from pregnant Wistar rats females treated with immunosuppressive regimen