PXD035545 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | the analysis of sus scrofa serum LC-MS/MS after african swine fever virus infection |
Description | African swine fever (ASF) is the most dangerous disease of pigs and causes enormous economic losses in the global pig industry. However, the mechanism of ASF virus (ASFV) infection is unclear. Hence, we wanted to understand the host response mechanism upon ASFV infection. We analyzed the differentially expressed proteins (DEPs) between ASFV-infected and un-infected serum samples using quantitative proteomics. Setting the p-value < 0.05 and |log2 (fold change)| > 1.5, we identified 173 DEPs, including 57 upregulated and 116 downregulated proteins, which belonged to various biological processes and pathways according to the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. The enriched pathways include the immune system, metabolism, and inflammation. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:22:33.232.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Changjie Lv |
SpeciesList | scientific name: Viruses; NCBI TaxID: NCBITaxon:10239; scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-24 05:15:55 | ID requested | |
1 | 2022-10-12 04:53:25 | announced | |
⏵ 2 | 2023-11-14 07:22:37 | announced | 2023-11-14: Updated project metadata. |
Publication List
Lv C, Zhang Q, Zhao L, Yang J, Zou Z, Zhao Y, Li C, Sun X, Lin X, Jin M, African swine fever virus infection activates inflammatory responses through downregulation of the anti-inflammatory molecule C1QTNF3. Front Immunol, 13():1002616(2022) [pubmed] |
Keyword List
submitter keyword: sus scrofa serum LC-MS/MS |
Contact List
Changjie Lv |
contact affiliation | College of Veterinary Medicine, Huazhong Agricultural University |
contact email | 1091367106@qq.com |
lab head | |
Changjie Lv |
contact affiliation | huazhong agriculture university |
contact email | 1091367106@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035545
- Label: PRIDE project
- Name: the analysis of sus scrofa serum LC-MS/MS after african swine fever virus infection