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PXD035545

PXD035545 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlethe analysis of sus scrofa serum LC-MS/MS after african swine fever virus infection
DescriptionAfrican swine fever (ASF) is the most dangerous disease of pigs and causes enormous economic losses in the global pig industry. However, the mechanism of ASF virus (ASFV) infection is unclear. Hence, we wanted to understand the host response mechanism upon ASFV infection. We analyzed the differentially expressed proteins (DEPs) between ASFV-infected and un-infected serum samples using quantitative proteomics. Setting the p-value < 0.05 and |log2 (fold change)| > 1.5, we identified 173 DEPs, including 57 upregulated and 116 downregulated proteins, which belonged to various biological processes and pathways according to the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. The enriched pathways include the immune system, metabolism, and inflammation.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:22:33.232.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChangjie Lv
SpeciesList scientific name: Viruses; NCBI TaxID: NCBITaxon:10239; scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-24 05:15:55ID requested
12022-10-12 04:53:25announced
22023-11-14 07:22:37announced2023-11-14: Updated project metadata.
Publication List
Lv C, Zhang Q, Zhao L, Yang J, Zou Z, Zhao Y, Li C, Sun X, Lin X, Jin M, African swine fever virus infection activates inflammatory responses through downregulation of the anti-inflammatory molecule C1QTNF3. Front Immunol, 13():1002616(2022) [pubmed]
Keyword List
submitter keyword: sus scrofa serum LC-MS/MS
Contact List
Changjie Lv
contact affiliationCollege of Veterinary Medicine, Huazhong Agricultural University
contact email1091367106@qq.com
lab head
Changjie Lv
contact affiliationhuazhong agriculture university
contact email1091367106@qq.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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