PXD035501

PXD035501 is an original dataset announced via ProteomeXchange.

Title	Identification of novel SCF FBXW7 substrates in asynchronous and mitotic cells
Description	FBXW7 loss-of-function has been implicated in chemoresistance against antimicrotubule drugs. FBXW7 is frequently mutated in human cancers and the identification of FBXW7 substrates, which could be involved in this phenotype, is a major task.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:57:31.256.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simon Haenle-Kreidler
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-21 08:19:26	ID requested
1	2022-12-02 06:13:08	announced
⏵ 2	2023-11-14 07:57:33	announced	2023-11-14: Updated project metadata.

H, ä, nle-Kreidler S, Richter KT, Hoffmann I, The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage. J Biol Chem, 298(12):102703(2022) [pubmed]

submitter keyword: FBXW7, ubiquitination, cell cycle

Ingrid Hoffmann
contact affiliation	Cell Cycle Control and Carcinogenesis, F045, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
contact email	ingrid.hoffmann@dkfz-heidelberg.de
lab head
Simon Haenle-Kreidler
contact affiliation	Cell Cycle Control and Carcinogenesis, F045, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
contact email	s.haenle@dkfz-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD035501

PRIDE project URI

• PRIDE
  1. PXD035501
     1. Label: PRIDE project
     2. Name: Identification of novel SCF FBXW7 substrates in asynchronous and mitotic cells