PXD035495 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Positive feedback between TOR singling, energy metabolism and lysine acetylation drives heterosis in elite hybrid rice |
Description | Heterosis refers to the superior performance of the hybrid compared with its parental lines. Despite several genetic models and different molecular pathways proposed to explain heterosis, it remains unclear how hybrid cells integrate complementary gene expression, metabolic accumulation and/or hormone signaling to drive heterotic growth. In this work, using integrative omics combined with biochemical analyses, we uncovered an enhanced TORC1 signaling in the elite hybrid rice Shanyou 63 (SY63) relative to the parental lines, which was associated with accumulation of growth-promoting (translation, cell division) and energy metabolic (glycolysis and TCA) proteins, enhanced energy metabolic activities, increased histone H3 and cellular protein lysine acetylation, and superior growth of the panicle meristem. Metabolism of nuclear-cytosolic acetyl-Coenzyme A was also enhanced in the hybrid, which paralleled with increases of histone H3 acetylation to selectively target growth-promoting and metabolic genes expression. Lysine acetylation of cellular proteins including TORC1, ribosomal proteins, and energy metabolic enzymes was also augmented and/or remodeled, potentially modulating their activities. The data indicate that the positive feedback loop between TOR-signaling, energy-producing metabolic activity, lysine acetylation, and growth-promoting gene expression is a mechanism underling the superior growth rate of the hybrid. The results imply that any enhanced activity within the loop would drive and sustain the TOR signaling to promote superior growth of hybrids, which may represent a general mechanistic model for heterosis. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_09:07:25.603.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xuan Ma |
SpeciesList | scientific name: Oryza sativa (Rice); NCBI TaxID: 4530; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-21 07:46:45 | ID requested | |
1 | 2023-10-24 11:22:25 | announced | |
⏵ 2 | 2023-11-14 09:07:30 | announced | 2023-11-14: Updated project metadata. |
Publication List
Ma X, Jia Q, Li S, Chen Z, Ming X, Zhao Y, Zhou DX, An enhanced network of energy metabolism, lysine acetylation, and growth-promoting protein accumulation is associated with heterosis in elite hybrid rice. Plant Commun, 4(4):100560(2023) [pubmed] |
Keyword List
submitter keyword: Hybrid rice;Proteome;TORC1;lysine acetylation |
energy metabolism |
Contact List
Xuan Ma |
contact affiliation | National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, 430070 Wuhan, China |
contact email | maxuan@webmail.hzau.edu.cn |
lab head | |
Xuan Ma |
contact affiliation | National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University |
contact email | maxuan@webmail.hzau.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035495
- Label: PRIDE project
- Name: Positive feedback between TOR singling, energy metabolism and lysine acetylation drives heterosis in elite hybrid rice