PXD035495

PXD035495 is an original dataset announced via ProteomeXchange.

Title	Positive feedback between TOR singling, energy metabolism and lysine acetylation drives heterosis in elite hybrid rice
Description	Heterosis refers to the superior performance of the hybrid compared with its parental lines. Despite several genetic models and different molecular pathways proposed to explain heterosis, it remains unclear how hybrid cells integrate complementary gene expression, metabolic accumulation and/or hormone signaling to drive heterotic growth. In this work, using integrative omics combined with biochemical analyses, we uncovered an enhanced TORC1 signaling in the elite hybrid rice Shanyou 63 (SY63) relative to the parental lines, which was associated with accumulation of growth-promoting (translation, cell division) and energy metabolic (glycolysis and TCA) proteins, enhanced energy metabolic activities, increased histone H3 and cellular protein lysine acetylation, and superior growth of the panicle meristem. Metabolism of nuclear-cytosolic acetyl-Coenzyme A was also enhanced in the hybrid, which paralleled with increases of histone H3 acetylation to selectively target growth-promoting and metabolic genes expression. Lysine acetylation of cellular proteins including TORC1, ribosomal proteins, and energy metabolic enzymes was also augmented and/or remodeled, potentially modulating their activities. The data indicate that the positive feedback loop between TOR-signaling, energy-producing metabolic activity, lysine acetylation, and growth-promoting gene expression is a mechanism underling the superior growth rate of the hybrid. The results imply that any enhanced activity within the loop would drive and sustain the TOR signaling to promote superior growth of hybrids, which may represent a general mechanistic model for heterosis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:07:25.603.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xuan Ma
SpeciesList	scientific name: Oryza sativa (Rice); NCBI TaxID: 4530;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-21 07:46:45	ID requested
1	2023-10-24 11:22:25	announced
⏵ 2	2023-11-14 09:07:30	announced	2023-11-14: Updated project metadata.

Ma X, Jia Q, Li S, Chen Z, Ming X, Zhao Y, Zhou DX, An enhanced network of energy metabolism, lysine acetylation, and growth-promoting protein accumulation is associated with heterosis in elite hybrid rice. Plant Commun, 4(4):100560(2023) [pubmed]

submitter keyword: Hybrid rice;Proteome;TORC1;lysine acetylation

energy metabolism

Xuan Ma
contact affiliation	National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, 430070 Wuhan, China
contact email	maxuan@webmail.hzau.edu.cn
lab head
Xuan Ma
contact affiliation	National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University
contact email	maxuan@webmail.hzau.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD035495
     1. Label: PRIDE project
     2. Name: Positive feedback between TOR singling, energy metabolism and lysine acetylation drives heterosis in elite hybrid rice