PXD035474

PXD035474 is an original dataset announced via ProteomeXchange.

Title	Multi-organ proteomic and phosphoproteomic landscape of K18-hACE2 mice infected with SARS-CoV-2
Description	Eight 10-week-old female K18-hACE2 mice were equally divided into control (n = 4) and virus-infected group (n = 4). Mice in the virus-infected group were challenged with 10^5 median tissue culture infective dose (TCID50) of SARS-CoV-2 virus by intranasal inoculation and mice in the control group were treated with equal volumes of PBS. On 5 days post infection (dpi), all the mice were euthanized and their cortex, hippocampus, thalamus, lung, and kidney were harvested for viral load detection, morphological analysis, and LC-MS-based label-free proteome and phosphoproteome analysis.
HostingRepository	iProX
AnnounceDate	2022-07-21
AnnouncementXML	Submission_2023-08-31_18:32:45.512.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiangfeng Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-21 00:51:08	ID requested
⏵ 1	2023-08-31 18:32:47	announced

Liu JF, Peng WJ, Wu Y, Yang YH, Wu SF, Liu DP, Liu JN, Yang JT, Proteomic and phosphoproteomic characteristics of the cortex, hippocampus, thalamus, lung, and kidney in COVID-19-infected female K18-hACE2 mice. EBioMedicine, 90():104518(2023) [pubmed]

submitter keyword: COVID-19, label free, proteomics, phosphoproteomics, K18-hACE2 mice, multi-organ

Juntao Yang
contact affiliation	Peking Union Medical College
contact email	yangjt@pumc.edu.cn
lab head
Jiangfeng Liu
contact affiliation	Peking Union Medical College
contact email	ljf@pumc.edu.cn
dataset submitter

iProX dataset URI