PXD035473

PXD035473 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis reveals novel function of DDRGK1 in osteosarcoma
Description	DDRGK1 is identified as a target of ufymaltion, while its function in tumor is still largely unknown and even controversial according to recent study. To invesgate the role of DDRGK1 in osteosarcoma, DDRGK1 gene was knockout in 143B cells by CRISPR/cas9, and recombinant DDRGK1 protein was added in the cell culture medium and stimulated for 24h. whole cell protein extracts were harvested and TMT-labelled proteomics analysis was performed.
HostingRepository	iProX
AnnounceDate	2022-07-21
AnnouncementXML	Submission_2023-05-22_00:45:35.224.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-20 22:07:43	ID requested
1	2022-07-20 22:07:56	announced
⏵ 2	2023-05-22 00:45:36	announced	2023-05-22: Update publication information.

Wang X, Zhou T, Yang X, Cao X, Jin G, Zhang P, Guo J, Rong K, Li B, Hu Y, Liu K, Ma P, Qin A, Zhao J, DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination. Adv Sci (Weinh), 10(14):e2204438(2023) [pubmed]

submitter keyword: DDRGK1, osteosarcoma

Jie Zhao
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	prozhaojie@126.com
lab head
Xin Wang
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	walsheim@163.com
dataset submitter

iProX dataset URI