PXD035386
PXD035386 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Intake of high dairy products modifies the correlation between a-tocopherol levels and serum proteins related to lipid metabolism in subjects at risk of type 2 diabetes |
| Description | The aim of this study is to investigate the relationship between a-tocopherol levels and serum protein profiles in human subjects at risk of T2D before and after intake of adequate dairy (AD) or high dairy (HD) products. In this crossover study, dietary intake of 25 subjects with hyperinsulinemia included: 1- pre-AD intake; 2- pre-HD intake; 3- post- AD intake (less or equal 2 servings/day); and 4- post-HD intake (more or equal than 4 servings/day) assessed by food frequency questionnaire. At each intake, serum a-tocopherol level was measured by gas chromatography-spectrometry and serum proteins were identified and quantified by liquid chromatography-mass spectrometry. Spearman correlation and gene ontology analyses were performed to identify biological pathways affected by dairy intake. a-tocopherol levels were associated with proteins that regulate lipid homeostasis and immune response. However, the increase intake of dairy products modified these associations in subjects with T2D. |
| HostingRepository | MassIVE |
| AnnounceDate | 2022-12-12 |
| AnnouncementXML | Submission_2022-12-12_08:13:34.455.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michel Lebel |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-07-19 08:08:33 | ID requested | |
| ⏵ 1 | 2022-12-12 08:13:34 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Vitamin E, a-tocopherol, type 2 diabetes, dairy products, mass spectrometry, serum proteomic profile. |
Contact List
| Michel Lebel | |
|---|---|
| contact affiliation | Centre Hospitalier Universite Laval |
| contact email | michel.lebel@crchudequebec.ulaval.ca |
| lab head | |
| Michel Lebel | |
| contact affiliation | CHudeQuebe |
| contact email | michel.lebel@crchudequebec.ulaval.ca |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000089916/ |
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