PXD035379

PXD035379 is an original dataset announced via ProteomeXchange.

Title	Label-free proteomic analysis of apoptotic, necrotic and necroptotic DAMPs from HNSCC cells
Description	Necroptosis is a newly discovered form of programmed cell death (PCD) showing necrotic features, including membrane permeabilization and the release of damage-associated molecular patterns (DAMPs). Studies have revealed both its tumorigenic role and therapeutic potential in various cancers, yet its impact on head and neck squamous cell carcinoma (HNSCC) is poorly understood. To investigate the differential composition of necroptotic DAMPs, SCC25 cells treated by TNF-α+Smac mimetic (TS), TNF-α+Smac mimetic+zVAD-fmk (TSZ) and Freeze-Thaw (FT) to induce apoptosis, necroptosis and necrosis respectively. Mass spectrum analysis was used to compare the differential compositions among DAMPs derived from apoptosis (TS), necroptosis (TSZ) and necrosis (FT).
HostingRepository	iProX
AnnounceDate	2022-07-16
AnnouncementXML	Submission_2022-07-19_05:46:31.457.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jingyuan Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-19 05:41:22	ID requested
⏵ 1	2022-07-19 05:46:31	announced

Dataset with its publication pending

submitter keyword: Necroptosis, Head and neck cancer, DAMPs

Yujie Liang
contact affiliation	Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University
contact email	liangyj35@mail.sysu.edu.cn
lab head
Jingyuan Li
contact affiliation	Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University
contact email	lijy679@mail.sysu.edu.cn
dataset submitter

iProX dataset URI