PXD035379
PXD035379 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Label-free proteomic analysis of apoptotic, necrotic and necroptotic DAMPs from HNSCC cells |
| Description | Necroptosis is a newly discovered form of programmed cell death (PCD) showing necrotic features, including membrane permeabilization and the release of damage-associated molecular patterns (DAMPs). Studies have revealed both its tumorigenic role and therapeutic potential in various cancers, yet its impact on head and neck squamous cell carcinoma (HNSCC) is poorly understood. To investigate the differential composition of necroptotic DAMPs, SCC25 cells treated by TNF-α+Smac mimetic (TS), TNF-α+Smac mimetic+zVAD-fmk (TSZ) and Freeze-Thaw (FT) to induce apoptosis, necroptosis and necrosis respectively. Mass spectrum analysis was used to compare the differential compositions among DAMPs derived from apoptosis (TS), necroptosis (TSZ) and necrosis (FT). |
| HostingRepository | iProX |
| AnnounceDate | 2022-07-16 |
| AnnouncementXML | Submission_2025-06-30_01:04:13.199.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jingyuan Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-07-19 05:41:22 | ID requested | |
| 1 | 2022-07-19 05:46:31 | announced | |
| ⏵ 2 | 2025-06-30 01:04:14 | announced | 2025-06-30: Add info |
Publication List
| Li J, Tan J, Wang T, Yu S, Guo G, Li K, Yang L, Zeng B, Mei X, Gao S, Lao X, Zhang S, Liao G, Liang Y, cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer. Exp Hematol Oncol, 13(1):63(2024) [pubmed] |
Keyword List
| submitter keyword: Necroptosis, Head and neck cancer, DAMPs |
Contact List
| Yujie Liang | |
|---|---|
| contact affiliation | Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University |
| contact email | liangyj35@mail.sysu.edu.cn |
| lab head | |
| Jingyuan Li | |
| contact affiliation | Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University |
| contact email | lijy679@mail.sysu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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