PXD035367

PXD035367 is an original dataset announced via ProteomeXchange.

Title	Analysis of protein expression changes in patients with prediabetes using high-throughput proteomics
Description	Objective: This study aimed to explore the mechanisms of early-onset T2DM by analyzing proteomic changes at different stages of glucose metabolism. Methods: A total of 40 individuals undergoing routine physical health examinations between December 2016 and April 2017 were enrolled. Subjects were divided into four groups based on fasting blood glucose (FPG) levels: 10 cases with FPG <5.6 mmol/L (group A); 10 cases with FPG ≥5.6 mmol/L and <6.1 mmol/L (group B); 10 cases with FPG ≥6.1 mmol/L and <7.0 mmol/L (group C); and 10 cases with FPG ≥7.0 mmol/L (group D). Results of differential proteomic analysis performed by label-free quantification were compared with metabolites determined by metabolomics. Results: A total of 277 differentially expressed proteins were screened and were identified as mainly secreted proteins. Comparing group A with group B, 32 proteins were up-regulated (fold change >1.2; p <0.05) and 18 proteins were down-regulated (fold change <-1.2; p <0.05). Comparing group B with group C, 3 pro
HostingRepository	iProX
AnnounceDate	2022-10-19
AnnouncementXML	Submission_2023-12-06_20:15:26.399.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huan Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-17 19:49:01	ID requested
1	2022-07-17 19:49:12	announced
⏵ 2	2023-12-06 20:15:27	announced	2023-12-07: Update publication.

Li H, Xie X, Liu H, Zhang L, Qiang D, Li L, He YT, Bai G, Analysis of protein expression changes in patients with prediabetes using proteomics approaches. Rapid Commun Mass Spectrom, 37(5):e9448(2023) [pubmed]

submitter keyword: prediabetes, high-throughput proteomics, CD14, CSF-1R

Xiaomin Xie
contact affiliation	The First People's Hospital of Yinchuan
contact email	xiaominxie@inbox.lv
lab head
Huan Li
contact affiliation	The First People's Hospital of Yinchuan
contact email	nfmk7167@126.com
dataset submitter

iProX dataset URI