PXD035365
PXD035365 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Disrupting metformin adaptation of hepatocellular carcinoma by targeting TOMM34/ATP5B axis |
| Description | As a well-known anti-diabetic drug, metformin has been repurposed for cancer treatment, but drug resistance and tumor metastasis observed recently have challenged its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characterized by obvious epithelial-mesenchymal transition (EMT) phenotype and compensatory elevated oxidative phosphorylation (OXPHOS). TOMM34, a translocase of the outer mitochondrial membrane, was identified to confer energetic flexibility thus promoting tumor metastasis in response to metformin-induced metabolic stress. Mechanistically, TOMM34 interacted and stabilized ATP5B to preserve F1F0-ATPase activity, which promoted mitochondrial OXPHOS and increased cellular ATP levels. This metabolic preference to OXPHOS suggested a large demand of energy supply of cancer cells to survival and spread under therapeutic stress. |
| HostingRepository | iProX |
| AnnounceDate | 2022-07-14 |
| AnnouncementXML | Submission_2022-12-24_20:54:30.961.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ping Jin |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-07-17 19:38:06 | ID requested | |
| 1 | 2022-07-17 19:38:26 | announced | |
| ⏵ 2 | 2022-12-24 20:54:31 | announced | 2022-12-25: Update publication information. |
Publication List
| Jin P, Jiang J, Zhou L, Huang Z, Qin S, Chen HN, Peng L, Zhang Z, Li B, Luo M, Zhang T, Ming H, Ding N, Li L, Xie N, Gao W, Zhang W, Nice EC, Wei Y, Huang C, Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis. EMBO Mol Med, 14(12):e16082(2022) [pubmed] |
Keyword List
| submitter keyword: Metformin, Metabolic adaptation, Hepatocellular carcinoma, Metastasis, OXPHOS |
Contact List
| Canhua Huang | |
|---|---|
| contact affiliation | Sichuan University |
| contact email | 1665705251@qq.com |
| lab head | |
| Ping Jin | |
| contact affiliation | Sichuan University |
| contact email | 654504559@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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