PXD035331

PXD035331 is an original dataset announced via ProteomeXchange.

Title	Data in support of TNF inhibition in experimental rotator cuff tear mouse model
Description	Musculoskeletal injuries related to the rotator cuff (RC) are frequent and account for up to 70% of shoulder pain problems. Lesions of the RC lead to weakness and pain (ref: Carr et al mfl) and untreated these lesions are acompanied by muscle degeneration modulated by inflammatory reactions that vary in intensity. Anti-inflammatory modalities such as NSAID and corticosteroids are commonly used as add ons to conservative treatment of RC tendon tears or RC tendon surgery, which are, however associated with high failure rates. The aim was to study the impact that a conventional TNF inhibitor and a super selective TNF inhibitor (Anti-TNF treatment) has on soft tissue inflammation and bone constituent parameters/connective tissue in a rotator cuff tear model.
HostingRepository	PRIDE
AnnounceDate	2026-01-12
AnnouncementXML	Submission_2026-01-12_09:05:55.495.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Allan Stensballe
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-14 06:13:55	ID requested
⏵ 1	2026-01-12 09:05:56	announced

10.1042/bsr20253559;

Aboo C, Lambertsen KL, Nasseri S, Ding M, Jensen PT, Linh Ta TM, Ditzel N, Schr, ø, der HD, Stensballe A, Hejb, ø, l EK, Frich LH, The effect of the nonselective TNF inhibitor etanercept and of the selective TNF inhibitor XPro1595 on lesioned supraspinatus muscle. Biosci Rep, 45(12):(2025) [pubmed]

submitter keyword: proteomics, rotator cuff, mouse

Allan Stensballe
contact affiliation	Laboraotry for translational biomarkers and digital health
contact email	as@hst.aau.dk
lab head
Allan Stensballe
contact affiliation	Aalborg University
contact email	as@hst.aau.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD035331

PRIDE project URI

• PRIDE
  1. PXD035331
     1. Label: PRIDE project
     2. Name: Data in support of TNF inhibition in experimental rotator cuff tear mouse model