PXD035287

PXD035287 is an original dataset announced via ProteomeXchange.

Title	PHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and HCC Growth
Description	Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme in serine biosynthesis pathway. Here, we analyzed immunoprecipitated PHGDH from human HEK293T cells by liquid chromatography tandem mass spectrometry (LC-MS/MS), and identified the potential interacting proteins of PHGDH.
HostingRepository	iProX
AnnounceDate	2022-07-29
AnnouncementXML	Submission_2023-03-01_19:00:04.983.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	kui Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-13 05:11:49	ID requested
1	2022-07-13 05:12:07	announced
⏵ 2	2023-03-01 19:00:07	announced	2023-03-02: Update publication information.

Wang K, Luo L, Fu S, Wang M, Wang Z, Dong L, Wu X, Dai L, Peng Y, Shen G, Chen HN, Nice EC, Wei X, Huang C, PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. Nat Commun, 14(1):1011(2023) [pubmed]

submitter keyword: PHGDH interacting protein

Canhua Huang
contact affiliation	Sichuan University
contact email	hcanhua68@163.com
lab head
kui Wang
contact affiliation	Sichuan University
contact email	wangkui416@163.com
dataset submitter

iProX dataset URI