PXD035267

PXD035267 is an original dataset announced via ProteomeXchange.

Title	Proteins, possibly human, found in World War II concentration camp artifact
Description	Museums displaying artifacts of the human struggle against oppression are often caught in their own internal struggle between presenting factual and unbiased descriptions of their collections, or relying on testament of survivors. Often this quandary is resolved in favor of what can be verified, not what is remembered. However, with improving instrumentation, methods and informatic approaches, science can help uncover evidence able to reconcile memory and facts. Following World War II, thousands of small, cement-like disks with numbers impressed on one side were found at concentration camps throughout Europe. Survivors claimed these disks were made of human cremains, museums erred on the side of caution – without documentation of the claims, was it justifiable to present them as fact? The ability to detect species relevant biological material in these disks could help resolve this question. Proteomic mass spectrometry of five disks revealed all contained proteins, including collagens and hemoglobins, suggesting they were made, at least in part, of animal remains. A new protein/informatics approach to species identification showed that while human was not always identified as the top contributor, human was the most likely explanation for one disk. To our knowledge, this is the first demonstration of protein recovery from cremains.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_03:21:26.602.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD035267
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Erin Butler
SpeciesList	scientific name: Mammalia; NCBI TaxID: 40674;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	4800 Plus MALDI TOF/TOF

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-11 15:04:36	ID requested
⏵ 1	2022-08-12 03:21:27	announced

Yang H, Butler E, Monier SA, Siegel D, Proteins, possibly human, found in World War II concentration camp artifact. Sci Rep, 12(1):12369(2022) [pubmed]

submitter keyword: bone, cremains, species

Donald Siegel
contact affiliation	Office of Chief Medical Examiner of the City of New York
contact email	dsiegel@ocme.nyc.gov
lab head
Erin Butler
contact affiliation	Office of the Chief Medical Examiner New York City
contact email	erbutler@ocme.nyc.gov
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD035267
     1. Label: PRIDE project
     2. Name: Proteins, possibly human, found in World War II concentration camp artifact