PXD035231

PXD035231 is an original dataset announced via ProteomeXchange.

Title	Candida albicans phosphoproteome analysis after exposure to hydrogen peroxide
Description	Invasive candidiasis is among the fungal infections that cause more deaths in the world in immunocompromised patients. The main species responsible for these infections is Candida albicans, an opportunistic pathogen found in the microbiota of healthy individuals; however, states of immunosuppression favor the develop-ment of systemic infections caused by this fungus. For this purpose it is essential to go deepen in the knowledge of C. albicans response to 10 mM of hydrogen peroxide. Four biological replicates of each condition were analyzed. For protein identification we employed a technological approach of mass spectrometry, "Shot-gun", allowing a high-throughput identification and quantification of nearby 2000 proteins. Changes in protein abundance after the treatment to hydrogen peroxide led to an increase in many proteins related to oxidative stress response, proteasome and protein folding while few proteins from mitochondria decreased their abundance. This proteomic study provided valuable information for the development of new drug targets against decisive proteins for cell survival
HostingRepository	PRIDE
AnnounceDate	2025-06-24
AnnouncementXML	Submission_2025-06-24_06:48:42.704.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD035231
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Concha Gil
SpeciesList	scientific name: Candida albicans SC5314; NCBI TaxID: 237561;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-11 08:07:29	ID requested
⏵ 1	2025-06-24 06:48:43	announced

10.1021/acs.jproteome.5c00137;

10.6019/PXD035231;

Arribas V, Borrajo A, Hern, á, ez ML, Mart, í, nez R, Monteoliva L, Gil C, Molero G, Exposed to Oxidative Stress. J Proteome Res, ():(2025) [pubmed]

submitter keyword: Candida albicans, Shotgun, phosphoproteome, oxidative stress, hydrogen peroxide

Concha Gil
contact affiliation	Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
contact email	conchagil@ucm.es
lab head
Concha Gil
contact affiliation	UCM
contact email	cai.proteomica@pas.ucm.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD035231
     1. Label: PRIDE project
     2. Name: Candida albicans phosphoproteome analysis after exposure to hydrogen peroxide