PXD035193

PXD035193 is an original dataset announced via ProteomeXchange.

Title	Impact of bacteriocin production on cellular metabolism of Staphylococcus aureus
Description	Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread amongst bacterial isolates and are important genetic determinants of competitive fitness. Staphylococci produce a tremendous diversity of compounds and the corresponding gene clusters (Staphylococcal Antibiosis Islands - SAbIs) are frequently associated with mobile genetic elements, suggesting acquisition and loss of biosynthetic capacity. Pharmaceutical biology has shown that transfer of BGCs between bacterial species is frequently challenging and production by the heterologous hosts often depends on optimal precursor supplies. It is unknown if transfer of SAbIs has similar effects. We modelled SAbItransfer between closely related S. aureus strains based on the SAbI encoding the ribosomally synthesized and post-translationally modified peptide (RiPP) Micrococcin P1 (MP1). Our results indicate that acquisition of SAbIs can represent a mixed blessing for the recipient strain and its genetic and metabolic predispositions are of crucial importance to integrate bacteriocin production into the cellular metabolism.
HostingRepository	PRIDE
AnnounceDate	2022-11-21
AnnouncementXML	Submission_2022-11-21_07:24:20.113.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MiritaFranz-Wachtel
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-09 08:50:11	ID requested
⏵ 1	2022-11-21 07:24:20	announced

Dataset with its publication pending

submitter keyword: bacteriocin production, citrate synthase, TCA,Staphylococcus aureus

SimonHeilbronner
contact affiliation	Interfaculty Institute of Microbiology and Infection Medicine, Institute for Medical Microbiology and Hygiene,UKT Tübingen, 72076 Tübingen, Germany.
contact email	simon.heilbronner@uni-tuebingen.de
lab head
MiritaFranz-Wachtel
contact affiliation	Proteome Center Tuebingen
contact email	mirita.franz@uni-tuebingen.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD035193
     1. Label: PRIDE project
     2. Name: Impact of bacteriocin production on cellular metabolism of Staphylococcus aureus