PXD035186
PXD035186 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Kinase activity profiling in breast cancer samples |
Description | In this study, we measured the kinase activity profiles of 32 pre-treatment tumour biopsies of HER2-positive breast cancer patients. The aim of this study was to assess the prognostic potential of kinase activity levels in prediction of treatment success against HER2-targeted therapy combined with chemotherapy. Indeed, our system-wide kinase activity analysis, based on targeted mass spectrometry measurement of kinase activation loops, allowed us to link kinase activity to treatment response. Overall, high kinase activity in the HER2-pathway was associated with good treatment outcome. Furthermore, we found eleven kinases differentially regulated between treatment outcome groups. |
HostingRepository | PanoramaPublic |
AnnounceDate | 2024-03-09 |
AnnouncementXML | Submission_2024-03-09_20:10:53.298.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Donna Olivia Debets |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | Phospho; Carbamidomethyl; Oxidation; Label:13C(6)15N(2); Label:13C(6)15N(4) |
Instrument | TSQ Altis |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-07-08 08:53:25 | ID requested | |
⏵ 1 | 2024-03-09 20:10:53 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Breast cancer, clinical, kinase activity, phosphorylation, treatment prediction |
Contact List
Maarten Altelaar | |
---|---|
contact affiliation | Utrecht University |
contact email | m.altelaar@uu.nl |
lab head | |
Donna Olivia Debets | |
contact affiliation | Utrecht University |
contact email | d.o.debets@uu.nl |
dataset submitter |
Full Dataset Link List
Panorama Public dataset URI |