PXD035113

PXD035113 is an original dataset announced via ProteomeXchange.

Title	Proteolytic degradation is the culprit behind a bioprosthetic heart valve failure
Description	Whereas the risk factors for structural valve deterioration (SVD) of glutaraldehyde (GA)- treated bioprosthetic heart valves (BHVs) are well-studied, those responsible for the failure of next-generation BHVs fixed with alternative chemicals remain largely unknown. Here, we collected 11 ethylene glycol diglycidyl ether (EGDE)-treated BHVs excised because of SVD and 5 calcified aortic valves (AVs) replaced with BHVs due to the calcific aortic valve disease (CAVD), further deciphering their proteomic profile.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:56:47.959.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD035113
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Arseniy Lobov
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-06 14:21:24	ID requested
1	2022-12-25 02:51:43	announced
⏵ 2	2023-11-14 08:56:48	announced	2023-11-14: Updated project metadata.

10.6019/PXD035113;

submitter keyword: Human, PASEF, TimsToF Pro, calcific aortic valve disease, bioprosthetic heart valve

Anton G. Kutikhin
contact affiliation	Laboratory of Molecular, Translational and Digital Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia
contact email	antonkutikhin@gmail.com
lab head
Arseniy Lobov
contact affiliation	Emmanuel Levy Lab, Dept. of Chemical and Structural Biology, Weizmann Institute of Science
contact email	arseniylobov@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD035113

PRIDE project URI

• PRIDE
  1. PXD035113
     1. Label: PRIDE project
     2. Name: Proteolytic degradation is the culprit behind a bioprosthetic heart valve failure